In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.

中文翻译：

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红辣椒种子水提取物抑制高脂饮食诱导的C57BL / 6小鼠肥胖。

在这项研究中，研究了红辣椒籽水提取物（RPS）对高脂饮食（HFD）喂养的小鼠肥胖的保护作用（HFD对照组和HFD组以100或200 mg / kg体重治疗RPS 13周）。RPS的应用部分逆转了HFD引起的体重和脂肪组织重量的增加。脂肪组织重量的模式与脂肪区域的模式平行，如DXA程序所测量。RPS在脂肪组织中抑制脂肪形成转录因子和脂肪标记基因的表达。通过RPS处理在脂肪组织中观察到AMP激活的蛋白激酶激活。此外，RPS改善了喂食HFD的小鼠的胰岛素抵抗和高脂血症的高稳态模型评估。