Immune thrombocytopenia (ITP) has been reported to be associated with thrombotic events. The incidence of thrombosis in 303 newly diagnosed ITP patients in our institute between 2000 and 2016 was retrospectively reviewed. During a median follow-up of 3.6 years, 16 thrombotic events (12 arterial and four venous) occurred. The median platelet count at thrombotic events was 102 × 109/l. At 10 years, the cumulative thrombosis incidence was 10%. A univariate analysis showed that smoking, hypertension, male gender, a history of thrombosis, and atrial fibrillation (Af) were significantly associated with the occurrence of thrombosis, and a multivariate analysis identified smoking and Af as independent risk factors. The thrombotic risk was not increased by lupus anticoagulant positivity or ITP treatment. At 5 years, the cumulative incidence of bleeding and overall survival probability was 5.6% and 92%, respectively. This study demonstrates that smoking and Af were associated with an increased risk of thrombosis. Previously identified risk factors were not confirmed in these Japanese ITP patients.

中文翻译：

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免疫性血小板减少症患者的血栓形成事件评估。

据报道，免疫性血小板减少症（ITP）与血栓形成事件有关。回顾性分析了我院2000年至2016年间303名新诊断ITP患者的血栓形成发生率。在3.6年的中位随访期间，发生了16例血栓事件（12例动脉和4例静脉）。血栓形成事件中的血小板计数中位数为102×109 / l。在10年时，累积血栓形成率为10％。单因素分析显示吸烟，高血压，男性，血栓形成史和心房颤动（Af）与血栓形成的发生密切相关，多因素分析确定吸烟和Af是独立的危险因素。狼疮抗凝剂阳性或ITP治疗不会增加血栓形成风险。5岁 出血的累积发生率和总生存率分别为5.6％和92％。这项研究表明，吸烟和房颤与血栓形成的风险增加有关。这些日本ITP患者中尚未确认先前确定的危险因素。