Although widely used as a preclinical model for studying cardiovascular diseases, there is a scarcity of in vivo hemodynamic measurements of the naïve murine system in multiple arterial and venous locations, from head-to-toe, and across sex and age. The purpose of this study is to quantify cardiovascular hemodynamics in mice at different locations along the vascular tree while evaluating the effects of sex and age. Male and female, adult and aged mice were anesthetized and underwent magnetic resonance imaging. Data were acquired from four co-localized vessel pairs (carotid/jugular, suprarenal and infrarenal aorta/inferior vena cava (IVC), femoral artery/vein) at normothermia (core temperature 37 ± 0.2 °C). Influences of age and sex on average velocity differ by location in arteries. Average arterial velocities, when plotted as a function of distance from the heart, decrease nearly linearly from the suprarenal aorta to the femoral artery (adult and aged males: − 0.33 ± 0.13, R²= 0.87; − 0.43 ± 0.10, R² = 0.95; adult and aged females: − 0.23 ± 0.07, R² = 0.91; − 0.23 ± 0.02, R² = 0.99). Average velocity of aged males and average volumetric flow of aged males and females tended to be larger compared to adult comparators. With cardiovascular disease as the leading cause of death and with the implications of cardiovascular hemodynamics as important biomarkers for health and disease, this work provides a foundation for sex and age comparisons in pathophysiology by collecting and analyzing hemodynamic data for the healthy murine arterial and venous system from head-to-toe, across sex and age.

中文翻译：

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体内MRI评估C57BL / 6小鼠从年龄到性别的从头到脚的动脉和静脉血流量

尽管被广泛用作研究心血管疾病的临床前模型，但体内缺乏从头到脚，从性别到年龄，从多个动脉和静脉位置对幼稚鼠系统进行血流动力学测量。这项研究的目的是在评估性别和年龄的影响的同时，对沿血管树不同位置的小鼠的心血管血液动力学进行量化。对雄性和雌性，成年和老年小鼠进行麻醉，并进行磁共振成像。在常温下（中心温度37±0.2°C），从四个共定位的血管对（颈/颈静脉，肾上和肾下主动脉/下腔静脉（IVC），股动脉/静脉）获取数据。年龄和性别对平均速度的影响因动脉位置而异。将平均动脉速度绘制为与心脏的距离的函数时，R ² = 0.87；− 0.43±0.10，R ²  = 0.95; 成年和老年女性：− 0.23±0.07，R ²  = 0.91；-0.23±0.02，R ²  = 0.99）。与成年比较者相比，老年男性的平均速度和老年男性和女性的平均体积流量趋向于更大。由于心血管疾病是主要的死亡原因，而心血管血流动力学是健康和疾病的重要生物标志物，这项工作通过收集和分析健康鼠动脉和静脉系统的血流动力学数据，为病理生理中的性别和年龄比较奠定了基础。从头到脚，跨越性别和年龄。