PURPOSE To compare liver stiffness measurements obtained from MR elastography with liver T1 relaxation times obtained from T1 mapping and T2 relaxation times obtained from T2 mapping for detection and staging of liver fibrosis. MATERIALS AND METHODS 223 patients with known or suspected liver disease underwent MRI of the liver with T1 mapping (Look-Locker sequence) and 2D SE-EPI MR elastography (MRE) sequences. 139 of these patients also underwent T2 mapping with radial T2 TSE sequence. Two readers (R1 & R2) measured liver stiffness, T1 relaxation times and T2 relaxation times. T1 and T2 times were correlated with stiffness measurements. ROC analysis was used to compare the performance of both techniques in discriminating fibrosis stage in 23 patients who underwent liver biopsy. RESULTS For each reader there was significant moderate positive correlation between liver MRE and liver T1 mapping (r = 0.49 and 0.36). There was significant moderate positive correlation between liver T2 mapping and each of MRE and T1 mapping for one of the readers (r = 0.40 and 0.27). AUC for differentiating early (F0-F2) from advanced (F3-F4) fibrosis in biopsied patients was 0.975 (R1) and 0.925 (R2) for MRE, 0.671 (R1) and 0.642 (R2) for T1 mapping and 0.671 (R1) and 0.743 (R2) for T2 mapping. Inter-reader agreement was good for MRE (ICC = 0.84) substantial for T1 mapping (0.94) and T2 mapping (0.96). CONCLUSIONS Liver T1 and T2 mapping showed moderate positive correlation with MR elastography. Accuracy of MRE is however superior to T1 and T2 mapping in the subset of patients who underwent liver biopsy. Accuracy of combination of MRE and T1 mapping/T2 mapping was not superior to MRE alone.

中文翻译：

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肝脏的T1映射，T2映射和MR弹性成像，以检测和分期肝纤维化。

目的比较从MR弹性成像获得的肝硬度测量值与从T1映射获得的肝脏T1弛豫时间和从T2映射获得的T2弛豫时间，以进行肝纤维化的检测和分期。材料与方法223例已知或疑似肝病的患者接受了T1映射（Look-Locker序列）和2D SE-EPI MR弹性成像（MRE）序列的肝脏MRI。这些患者中的139名还接受了放射状T2 TSE序列的T2定位。两名读者（R1和R2）测量了肝脏的硬度，T1放松时间和T2放松时间。T1和T2时间与刚度测量相关。使用ROC分析来比较这两种技术在23例行肝活检的患者中区分纤维化阶段的效果。结果对于每个读者，肝脏MRE与肝脏T1定位之间均存在显着的中度正相关（r = 0.49和0.36）。对于其中一名读者，肝脏T2映射与MRE和T1映射之间存在显着的中等正相关（r = 0.40和0.27）。活检患者中将早期（F0-F2）与晚期（F3-F4）纤维化区分开的AUC对于MRE为0.975（R1）和0.925（R2），对于T1映射为0.671（R1）和0.642（R2），以及0.671（R1） T2映射为0.743（R2）。阅读器之间的协议对于MRE（ICC = 0.84）很有好处，对于T1映射（0.94）和T2映射（0.96）来说是重要的。结论肝脏T1和T2标测与MR弹性成像显示中等正相关。然而，在接受肝活检的患者亚组中，MRE的准确性优于T1和T2定位。