Universally applicable RNA membrane-based microneedle system for transdermal drug delivery,Materials Horizons

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Universally applicable RNA membrane-based microneedle system for transdermal drug delivery
Materials Horizons ( IF 12.2 ) Pub Date : 2020-01-04 , DOI: 10.1039/c9mh01838g
Dajeong Kim _{1,

2,

3,

4} , Hyejin Kim _{1,

2,

3,

4} , Peter C. W. Lee _{4,

5,

6,

7,

8} , Jong Bum Lee _{1,

2,

3,

4}

Affiliation

The transdermal delivery of functional biomolecules has been widely achieved by microneedles in a non-invasive manner. However, establishing a simple and universal way to assure a stable loading of a large number of drugs is still imperative, particularly for the delivery of nucleic acid-based drugs. To address this issue, here, we present a universally applicable RNA membrane-coating system as a novel platform to manufacture purpose-oriented microneedles. Customization of RNA membrane-based microneedles is realized by large surface area, high cargo capacity, and controllable material properties of the RNA membrane and 3D-printing of customized scaffold microneedles in a purpose-oriented manner. In addition, simple covering with the RNA membrane facilitates the fabrication of RNA-coated microneedles regardless of the configuration and material of the scaffold. This study demonstrates the successful delivery of RNA along with various types of drugs by purpose-oriented microneedles. Taken together, our approach provides a general route towards the fabrication of tailor-made microneedles for efficient transdermal drug delivery.

中文翻译：

普遍适用的基于RNA膜的微针系统，用于透皮给药

功能性生物分子的透皮递送已经通过微针以无创方式广泛实现。然而，仍然必须建立一种简单且通用的方式来确保稳定地装载大量药物，特别是对于基于核酸的药物的输送。为了解决这个问题，在这里，我们提出一种普遍适用的RNA膜包衣系统，作为制造面向目标的微针的新型平台。基于RNA膜的微针的定制是通过大表面积，高载货量和可控的RNA膜材料特性以及以目标导向的方式对定制的支架微针进行3D打印来实现的。此外，不论支架的结构和材料如何，用RNA膜简单覆盖即可促进RNA包被的微针的制造。这项研究表明，通过针对性的微针可以成功地将RNA与各种类型的药物一起递送。综上所述，我们的方法为通向定制微针的制造提供了一条通用途径，以实现有效的透皮给药。

更新日期：2020-01-04

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