History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial.,Obesity

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History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial.
Obesity ( IF 4.2 ) Pub Date : 2020-01-03 , DOI: 10.1002/oby.22676
, Cora E Lewis ₁ , John P Bantle ₂ , Alain G Bertoni ₃ , George Blackburn ₄ , Frederick L Brancati ₅ , George A Bray ₆ , Lawrence J Cheskin ₅ , Jeffrey M Curtis ₇ , Caitlin Egan ₈ , Mary Evans ₉ , John P Foreyt ₁₀ , Siran Ghazarian ₁₁ , Bethany Barone Gibbs ₁₂ , Stephen P Glasser ₁ , Edward W Gregg ₁₃ , Helen P Hazuda ₁₄ , Louise Hesson ₁₅ , James O Hill ₁₆ , Edward S Horton ₁₇ , Van S Hubbard ₉ , John M Jakicic ₁₂ , Robert W Jeffery ₂ , Karen C Johnson ₁₈ , Steven E Kahn ₁₉ , Abbas E Kitabchi ₁₈ , Dalane Kitzman ₃ , William C Knowler ₂₀ , Edward Lipkin ₁₉ , Sara Michaels ₂₁ , Maria G Montez ₁₄ , David M Nathan ₂₂ , Ebenezer Nyenwe ₁₈ , Jennifer Patricio ₂₃ , Anne Peters ₁₁ , Xavier Pi-Sunyer ₂₃ , Henry Pownall ₁₀ , David M Reboussin ₃ , Donna H Ryan ₆ , Thomas A Wadden ₁₅ , Lynne E Wagenknecht ₃ , Holly Wyatt ₁₆ , Rena R Wing ₈ , Susan Z Yanovski ₉

Affiliation

University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Minnesota, Minneapolis, Minnesota, USA.
Wake Forest University, Winston-Salem, North Carolina, USA.
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Johns Hopkins University, Baltimore, Maryland, USA.
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA.
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Baylor College of Medicine, Houston, Texas, USA.
University of Southern California, Los Angeles, California, USA.
University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Joslin Diabetes Center, Boston, Massachusetts, USA.
The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
Southwestern American Indian Center, Shiprock, New Mexico, USA.
Massachusetts General Hospital, Boston, Massachusetts, USA.
St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA.

To examine the effects of an intensive lifestyle intervention (ILI) on cardiovascular disease (CVD), the Action for Health in Diabetes (Look AHEAD) trial randomized 5,145 participants with type 2 diabetes and overweight/obesity to a ILI or diabetes support and education. Although the primary outcome did not differ between the groups, there was suggestive evidence of heterogeneity for prespecified baseline CVD history subgroups (interaction P = 0.063). Event rates were higher in the ILI group among those with a CVD history (hazard ratio 1.13 [95% CI: 0.90‐1.41]) and lower among those without CVD (hazard ratio 0.86 [95% CI: 0.72‐1.02]).

中文翻译：

Look AHEAD 试验中的心血管疾病史、强化生活方式干预和心血管结果。

为了研究强化生活方式干预 (ILI) 对心血管疾病 (CVD) 的影响，糖尿病健康行动 (Look AHEAD) 试验将 5,145 名患有 2 型糖尿病和超重/肥胖的参与者随机分组，接受 ILI 或糖尿病支持和教育。尽管各组之间的主要结局没有差异，但有暗示证据表明预先指定的基线 CVD 病史亚组存在异质性（交互作用P = 0.063）。在有 CVD 病史的 ILI 组中，事件发生率较高（风险比 1.13 [95% CI：0.90-1.41]），而无 CVD 的 ILI 组事件发生率较低（风险比 0.86 [95% CI：0.72-1.02]）。

更新日期：2020-01-03

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