Some novel radiopaque biodegradable and biocompatible iodinated polymers based on poly-3-hydroxy butyrate (PHB) were obtained. Following the attachment of diethanol amine to PHB, the hydroxyl ends were capped with 4-iodobenzoic acid and 2,3,5-tri-iodobenzoic acid. In this manner, tri-novel radiopaque polymers were obtained. The resulting polymers were structurally characterized by NMR technique. They were evaluated with respect to their possible use as radiopaque implant biomaterials indicating X-ray visibility in a noninvasive manner using routine X-ray absorption imaging techniques. These polymers exhibited good radiopacity with conventional imaging X-ray techniques in vivo. Additionally, biocompatibility of these iodinated polymers was also evaluated. There were no signs of infection or abscess formation on the surgical area. These novel radiopaque PHBs should be promising biomaterials for a new-generation radiopaque materials.

中文翻译：

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可生物降解和生物相容性不透射线的碘化聚 3-羟基丁酸酯：合成、表征和体外/体内 X 射线可见性

获得了一些基于聚 3-羟基丁酸酯 (PHB) 的新型不透射线生物可降解和生物相容性碘化聚合物。在将二乙醇胺连接到 PHB 后，羟基末端用 4-碘苯甲酸和 2,3,5-三-碘苯甲酸封端。以这种方式，获得了三元新型不透射线聚合物。通过NMR技术对所得聚合物进行结构表征。使用常规 X 射线吸收成像技术，评估了它们作为不透射线植入物生物材料的可能用途，以非侵入性方式显示 X 射线可见性。这些聚合物在常规的体内 X 射线成像技术下表现出良好的射线不透性。此外，还评估了这些碘化聚合物的生物相容性。手术区域没有感染或脓肿形成的迹象。