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Cis interactions make immune checkpoint blockade more trans-parent.
Science Immunology ( IF 17.6 ) Pub Date : 2020-01-02 , DOI: 10.1126/sciimmunol.aba7107
Natasha Khatwani 1, 2 , Asha B Pillai 1, 2
Affiliation  

PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

中文翻译:

顺式相互作用使免疫检查点封锁更加透明。

PD-L1:CD80 顺式异二聚体形成优先阻断 CTLA-4 反式信号传导,同时允许 CD28 介导的效应 T 细胞活化。
更新日期:2020-01-04
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