Catalyst-Free Synthesis of 1,4-Dihydroquinolines and Pyrrolo[1,2-a]quinolines via Intermolecular [4+2]/[3+2] Radical Cyclization of N-Methylanilines with Alkynoates,Synthesis

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Catalyst-Free Synthesis of 1,4-Dihydroquinolines and Pyrrolo[1,2-a]quinolines via Intermolecular [4+2]/[3+2] Radical Cyclization of N-Methylanilines with Alkynoates
Synthesis ( IF 2.6 ) Pub Date : 2020-01-02 , DOI: 10.1055/s-0039-1691541
Zaigang Luo ₁ , Xinxin Han ₁ , Chenfu Liu ₂ , Qiannan Liu ₁ , Rui Li ₁ , Peng Liu ₃ , Xuemei Xu ₁

Affiliation

Intermolecular [4+2]/[3+2] radical annulation of N-methylanilines with alkynoates under metal- and photoredox-catalyst-free conditions provides a practical and efficient method to synthesize bioactive 1,4-dihydroquinolines and pyrrolo[1,2-a]quinolines in one pot in moderate to high overall yields.

中文翻译：

N-甲基苯胺与炔酸的分子间[4 + 2] / [3 + 2]自由基环化反应，无催化剂合成1,4-二氢喹啉和吡咯并[1,2-a]喹啉

在无金属和光氧化还原催化剂的条件下，N-甲基苯胺与链烷酸酯的分子间[4 + 2] / [3 + 2]自由基环化提供了一种实用有效的方法来合成具有生物活性的1,4-二氢喹啉和吡咯并[1,2] -一锅中的]]喹啉总产量适中至较高。

更新日期：2020-01-04

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