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Self-Assembling l-d-l-Tripeptides Dance the Twist
Synlett ( IF 1.7 ) Pub Date : 2020-01-03 , DOI: 10.1055/s-0039-1690776
Maria C. Cringoli 1 , Ottavia Bellotto 1 , Rita De Zorzi 1 , Attilio V. Vargiu 2 , Silvia Marchesan 1
Affiliation  

Minimalistic peptides composed of d - and l -amino acids are attractive building blocks for functional supramolecular materials, including catalysts. d -Amino acids have long been known to promote turn conformations in peptides, yet unexpected twists continue to emerge on their effects on self-assembly. The combination of single-crystal X-ray diffraction and full-atom molecular dynamics have finally unraveled fine details of how l-d-l -tripeptides visit different conformations in solution and establish key interactions in supramolecular structures.

中文翻译:

自组装 ldl-三肽舞曲

由 d - 和 l - 氨基酸组成的极简肽是功能性超分子材料(包括催化剂)的有吸引力的构建模块。d-氨基酸长期以来一直被认为可以促进肽中的转角构象,但它们对自组装的影响继续出现意想不到的扭曲。单晶 X 射线衍射和全原子分子动力学的结合最终揭示了 ldl -三肽如何访问溶液中的不同构象并在超分子结构中建立关键相互作用的细节。
更新日期:2020-01-03
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