BACKGROUND Pheochromocytoma (PCC) has poor prognosis and adrenalectomy is hard to be performed, in case of caudal vena cava invasion. The long-term administration of phenoxybenzamine in PCC has not been reported in dogs. CASE PRESENTATION A 14-year-old castrated male Poodle dog presented with an abdominal mass. On physical examination, hypertension, increased lens opacity, calcinosis cutis, generalized alopecia, and systolic murmur were observed. Serum chemistry and urinalysis profiles revealed hyperglycemia, hypercholesterolemia, elevated liver enzymes, and glucosuria. Abdominal ultrasonography showed a right adrenal mass with invasion of the caudal vena cava, which was cytologically diagnosed as suspected PCC. An adrenal mass (width × height × length, 28 × 26 × 48 mm3) was found on computed tomography and diagnosed as PCC with increased plasma metanephrines and normetanephrines. An adrenocorticotropin hormone stimulation test showed elevated adrenal hormones (androstenedione, estradiol, progesterone, and 17-OH progesterone) with normal cortisol, compatible with atypical Cushing's syndrome. The dog was managed with trilostane, phenoxybenzamine, and insulin therapy. Glycosylated hemoglobin and fructosamine levels gradually decreased, and hypertension resolved. In the 10-month follow-up period, the liver enzymes levels gradually decreased, and the clinical signs of the dog were well-controlled without deterioration. CONCLUSIONS This case report describes long-term medical management without adrenalectomy of PCC complicated with atypical Cushing's syndrome and DM.

中文翻译：

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治疗后非典型库欣综合症和糖尿病犬的嗜铬细胞瘤转归良好：1例。

背景嗜铬细胞瘤（PCC）的预后较差，在尾腔静脉浸润的情况下很难进行肾上腺切除术。尚未在犬中报告PCC中苯氧苯甲胺的长期给药。病例介绍一只14岁的cast割的雄性贵宾犬呈现腹部肿块。在体格检查中，观察到高血压，晶状体混浊增加，皮肤角质层结皮，全身性脱发和收缩期杂音。血清化学和尿液分析显示高血糖，高胆固醇血症，肝酶升高和糖尿。腹部超声检查显示右肾上腺肿块侵犯了尾腔静脉，根据细胞学诊断为可疑PCC。肾上腺肿块（宽×高×长，在计算机X线断层扫描上发现28×26×48 mm3），并被诊断为PCC，血浆中肾上腺素和去甲肾上腺素增加。肾上腺皮质激素刺激试验显示，肾上腺激素（雄烯二酮，雌二醇，孕酮和17-OH孕酮）水平升高，皮质醇水平正常，与非典型库欣综合症相容。这只狗接受了Trilostane，苯氧基苯甲胺和胰岛素治疗。糖基化血红蛋白和果糖胺水平逐渐降低，高血压得以缓解。在10个月的随访期中，肝酶水平逐渐降低，并且犬的临床体征得到了良好控制，而没有恶化。结论该病例报告描述了不进行PCC肾上腺切除术并伴有非典型库欣综合征和DM的长期医疗管理。