BACKGROUND Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats. METHODS Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals. RESULTS Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically. CONCLUSIONS Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.

中文翻译：

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Liv-52对大鼠肝脏缺血再灌注损伤的影响。

背景技术在临床肝胆外科中经常见到的肝缺血再灌注（I / R）损伤没有有效的治疗方法。Liv-52已知具有保肝作用，是印度卫生部许可的天然抗氧化剂。我们研究的目的是研究Liv-52对I / R诱导的大鼠肝损伤的影响。方法将白化Wistar雄性大鼠分为三组。肝脏I / R（IR），20 mg / kg Liv-52 +肝脏缺血再灌注（LIR）和假手术应用于对照组（HG）。在I / R施用前1小时，将Liv-52施用至LIR组（n = 6），并以IR（n = 6）和HG（n = 6）组作为溶剂口服蒸馏水。在动物中，缺血被确定为1小时，再灌注被确定为6小时。结果丙氨酸转氨酶水平升高，天冬氨酸转氨酶和乳酸脱氢酶，丙二醛，髓过氧化物酶以及因I / R施用引起的超氧化物歧化酶和谷胱甘肽相关酶水平的降低已通过Liv-52治疗达到了健康组水平，并且肝脏组织的损伤在组织病理学上得到了改善。结论Liv-52可能有助于预防术前应用中肝脏I / R损伤。