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Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco‐2 cell line model
International Journal of Food Science & Technology ( IF 2.6 ) Pub Date : 2020-01-02 , DOI: 10.1111/ijfs.14466 Yun Peng 1 , Junjun Xi 1 , Yue Sun 1 , Guijie Chen 2 , Daxiang Li 1 , Chuanyi Peng 1 , Xiaochun Wan 1 , Huimei Cai 1
International Journal of Food Science & Technology ( IF 2.6 ) Pub Date : 2020-01-02 , DOI: 10.1111/ijfs.14466 Yun Peng 1 , Junjun Xi 1 , Yue Sun 1 , Guijie Chen 2 , Daxiang Li 1 , Chuanyi Peng 1 , Xiaochun Wan 1 , Huimei Cai 1
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Previous work showed that the bioavailability of fluoride in dark tea was lower than NaF solution. However, limited information is available indicating the effects of tea components on the fluoride bioavailability. In this study, the effects of the components in tea on the bioavailability of fluoride were evaluated in the Caco‐2 cell line model. Additionally, the mechanism of effect of aluminium on fluoride transport was investigated. The result showed that 10–100 μm of epigallocatechin gallate (EGCG) could not influence fluoride transport. Al3+ significantly decreased fluoride transport in both apical‐basolateral and basolateral‐apical directions. Moreover, aluminium could form different forms of aluminium fluoride complexes, which were transported through Caco‐2 cells by different pathways. F− transport was mainly dependent on the paracellular pathway and active transport involving Cl− channels. The paracellular pathway played a predominant role in transport of AlF3. The paracellular pathway and active transport both participated in AlF2+ transport.
中文翻译：
茶成分影响氟的生物利用度及Caco-2细胞系模型中的潜在转运机制
先前的工作表明，黑茶中氟化物的生物利用度低于NaF溶液。但是，有限的信息可用，表明茶成分对氟化物生物利用度的影响。在这项研究中，在Caco-2细胞系模型中评估了茶中各成分对氟化物生物利用度的影响。此外，研究了铝对氟化物传输的影响机理。结果表明，表没食子儿茶素没食子酸酯（EGCG）的10-100μm不会影响氟化物的运输。Al 3+显着降低了氟在根尖-基底外侧和基底外侧-根尖方向的运输。此外，铝可能形成不同形式的氟化铝络合物，并通过不同的途径穿过Caco-2细胞。˚F -运输是主要依赖于旁细胞途径和主动运输涉及氯-信道。旁细胞途径在AlF 3的运输中起主要作用。细胞旁途径和主动转运均参与了AlF 2 +转运。
更新日期：2020-01-02
中文翻译：
茶成分影响氟的生物利用度及Caco-2细胞系模型中的潜在转运机制
先前的工作表明，黑茶中氟化物的生物利用度低于NaF溶液。但是，有限的信息可用，表明茶成分对氟化物生物利用度的影响。在这项研究中，在Caco-2细胞系模型中评估了茶中各成分对氟化物生物利用度的影响。此外，研究了铝对氟化物传输的影响机理。结果表明，表没食子儿茶素没食子酸酯（EGCG）的10-100μm不会影响氟化物的运输。Al 3+显着降低了氟在根尖-基底外侧和基底外侧-根尖方向的运输。此外，铝可能形成不同形式的氟化铝络合物，并通过不同的途径穿过Caco-2细胞。˚F -运输是主要依赖于旁细胞途径和主动运输涉及氯-信道。旁细胞途径在AlF 3的运输中起主要作用。细胞旁途径和主动转运均参与了AlF 2 +转运。
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