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Comparative effects of surfactants on the behavior of an anticancer drug potentiometric sensor
Analytical Methods ( IF 2.7 ) Pub Date : 2020/01/03 , DOI: 10.1039/c9ay02252j Nasser Abu Ghalwa 1, 2, 3, 4 , Khalid I. Abed Almonem 1, 2, 3, 4 , Iyad D. Al-Kashef 1, 2, 3, 4 , Salman M. Saadeh 1, 3, 4, 5 , Hazem M. Abu Shawish 1, 3, 4, 6, 7
Analytical Methods ( IF 2.7 ) Pub Date : 2020/01/03 , DOI: 10.1039/c9ay02252j Nasser Abu Ghalwa 1, 2, 3, 4 , Khalid I. Abed Almonem 1, 2, 3, 4 , Iyad D. Al-Kashef 1, 2, 3, 4 , Salman M. Saadeh 1, 3, 4, 5 , Hazem M. Abu Shawish 1, 3, 4, 6, 7
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Surfactants may incorporate drug molecules in a micelle, allowing a great enhancement of a 5-fluorouracil electrode. The performance characteristics of electrodes comprising selected surfactants were investigated as well as the effect of their concentrations. These surfactants were benzalkonium chloride as a cationic surfactant, sodium dodecylsulfate as an anionic surfactant and Tween 20 and Tween 80 as non-ionic surfactants. In solutions of 5-fluorouracil in benzalkonium chloride the sensor showed the best response with a Nernstian slope of 29.5 mV per decade, a wide concentration range from 5.4 × 10−6 to 1.0 × 10−2 M, a notably low detection limit of 4.4 × 10−6 M and a significantly short response time (5 s). The electrode response is independent of the pH of the test solution in the range 3.2–9.5. Selectivity toward the drug ion was calculated for different inorganic cations, amino acids and pharmaceutical amines. Direct potentiometry and potentiometric titration were applied for the determination of 5-fluorouracil in its pure form and as an ampoule formulation and in urine.
中文翻译：
表面活性剂对抗癌药电位传感器行为的比较作用
表面活性剂可将药物分子掺入胶束中，从而大大增强了5-氟尿嘧啶电极。研究了包含所选表面活性剂的电极的性能特征及其浓度的影响。这些表面活性剂是作为阳离子表面活性剂的苯扎氯铵，作为阴离子表面活性剂的十二烷基硫酸钠和作为非离子表面活性剂的吐温20和吐温80。在苯扎氯铵中的5-氟尿嘧啶溶液中，传感器表现出最佳响应，每十年的Nernstian斜率为29.5 mV，浓度范围从5.4×10 -6到1.0×10 -2 M，检测限很低，仅为4.4 ×10 -6M，响应时间短（5 s）。电极响应与测试溶液的pH在3.2–9.5范围内无关。计算了不同无机阳离子，氨基酸和药物胺对药物离子的选择性。直接电位法和电位滴定法用于测定5-氟尿嘧啶的纯形式，安瓿形式和尿液中的含量。
更新日期：2020-02-13
中文翻译：
表面活性剂对抗癌药电位传感器行为的比较作用
表面活性剂可将药物分子掺入胶束中，从而大大增强了5-氟尿嘧啶电极。研究了包含所选表面活性剂的电极的性能特征及其浓度的影响。这些表面活性剂是作为阳离子表面活性剂的苯扎氯铵，作为阴离子表面活性剂的十二烷基硫酸钠和作为非离子表面活性剂的吐温20和吐温80。在苯扎氯铵中的5-氟尿嘧啶溶液中，传感器表现出最佳响应，每十年的Nernstian斜率为29.5 mV，浓度范围从5.4×10 -6到1.0×10 -2 M，检测限很低，仅为4.4 ×10 -6M，响应时间短（5 s）。电极响应与测试溶液的pH在3.2–9.5范围内无关。计算了不同无机阳离子，氨基酸和药物胺对药物离子的选择性。直接电位法和电位滴定法用于测定5-氟尿嘧啶的纯形式，安瓿形式和尿液中的含量。
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