Mesoporous yolk–shell structure molecularly imprinted magnetic polymers for the extraction and detection of 17β-estradiol,Analytical Methods

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Mesoporous yolk–shell structure molecularly imprinted magnetic polymers for the extraction and detection of 17β-estradiol
Analytical Methods ( IF 2.7 ) Pub Date : 2019/12/13 , DOI: 10.1039/c9ay02360g
Yinpeng Yang _{1,

2,

3,

4,

5} , Yuan Sun _{1,

2,

3,

4,

5} , Hang Chen _{1,

2,

3,

4,

5} , Xueping Dang _{1,

2,

3,

4,

5} , Youhong Ai _{1,

2,

3,

4,

5} , Xiaolan Liu _{1,

2,

3,

4,

5} , Huaixia Chen _{1,

2,

3,

4,

5}

Affiliation

Novel mesoporous yolk–shell structure magnetic molecularly imprinted polymers (MYS-MMIPs) were synthesized via surface polymerization using E2 as a template followed by chemical selective etching to remove the inorganic silica interlayer for the rapid, selective extraction and sensitive detection of 17β-estradiol (E2) in milk powder. For MYS-MMIPs, transmission electron microscopy coupled with N₂ adsorption experiments confirmed the successful formation of a mesoporous yolk–shell structure. Furthermore, the thermogravimetric and recycling experiments showed the good thermal and adsorption stability of MYS-MMIPs, the magnetic properties experiment confirmed their good magnetic response, and the binding experiment indicated their selective recognition and high binding capacity (39.24 mg g⁻¹) for E2. The obtained polymers were applied as adsorbents for the magnetic solid phase extraction (MSPE) of E2. After optimizing the MSPE conditions, an MSPE-HPLC method was developed for the determination of E2 in milk powder. The linear range was 1–300 μg kg⁻¹ with a limit of detection of 0.33 μg kg⁻¹. The satisfactory recoveries ranged from 88.3–102.4% and the relative standard deviations (RSDs) were lower than 5.5%. Thus, the MSPE-HPLC method has high accuracy and sensitivity for the analysis of E2 in milk samples.

中文翻译：

介孔卵黄壳结构分子印迹磁性聚合物用于17β-雌二醇的提取和检测

通过以E2为模板的表面聚合，然后化学选择性蚀刻以去除无机二氧化硅中间层，从而快速，选择性地提取和灵敏地检测17β-雌二醇，合成了新型的介孔卵黄-壳结构磁性分子印迹聚合物（MYS-MMIPs）（ E2）在奶粉中。对于MYS-MMIP，透射电子显微镜与N ₂耦合吸附实验证实成功形成了介孔的蛋黄壳结构。此外，热重和再循环实验表明MYS-MMIP具有良好的热稳定性和吸附稳定性，磁性能实验证实了其良好的磁响应，结合实验表明它们对E2的选择性识别和高结合能力（39.24 mg g ^-1）。。将获得的聚合物用作E2的磁性固相萃取（MSPE）的吸附剂。优化MSPE条件后，开发了MSPE-HPLC方法测定奶粉中的E2。线性范围为1–300μgkg ^-1，检出限为0.33μgkg ^-1。令人满意的回收率在88.3–102.4％之间，相对标准偏差（RSD）低于5.5％。因此，MSPE-HPLC方法对于分析牛奶样品中的E2具有很高的准确性和灵敏度。

更新日期：2020-02-13

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