Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots and their analytical application,Journal of Materials Chemistry B

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Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots and their analytical application
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-12-12 , DOI: 10.1039/c9tb02463h
Xiaofei Wang _{1,

2,

3,

4,

5} , Huiwen Liu _{1,

2,

3,

4,

5} , Honglan Qi _{1,

2,

3,

4,

5} , Qiang Gao _{1,

2,

3,

4,

5} , Chengxiao Zhang _{1,

2,

3,

4,

5}

Affiliation

The electrochemiluminescence (ECL) method has attracted increasing attention in analytical fields. However, ECL luminophores with high ECL efficiency both at positive and negative potentials still remain rare. Herein, we synthesized ruthenium complex-functionalized CdS quantum dots (QDs) with high ECL efficiency both at positive and negative potentials in aqueous solution. CdS QDs were chosen as the ECL donor while bis(2,2′-bipyridine)-(5-aminophenanthroline)ruthenium bis(hexafluorophosphate) (Ru-NH₂) was employed as the ECL acceptor. Ru-NH₂ was covalently coupled to the surface of CdS QDs via diazonium salt chemistry to form CdS–Ru nanoparticles. ECL resonance energy transfer (ECL-RET) occurred inside the CdS–Ru nanoparticles and strong ECL emissions were obtained from CdS–Ru nanoparticles at both positive potential in the presence of tri-n-propylamine and at negative potential in the presence of peroxydisulfate. Further, the combination of the excellent recognition ability of the aptamer and the good ECL behavior of CdS–Ru nanoparticles, as a proof-of-concept, showed that two sensitive ECL methods for the detection of thrombin were readily achieved under different ECL measurement conditions with a low detection limit of 0.6 pM and 0.7 pM. This work demonstrates that CdS–Ru nanoparticles with intramolecular ECL-RET are good ECL luminophores in the sensitive detection of targets, which is promising in multiple assays with spectrum-resolved and potential-resolved possibility for biological applications.

中文翻译：

钌配合物官能化CdS量子点的高效电化学发光及其分析应用

电化学发光（ECL）方法在分析领域引起了越来越多的关注。然而，在正电势和负电势都具有高ECL效率的ECL发光体仍然很少。在这里，我们合成了在水溶液中的正负电位下都具有高ECL效率的钌配合物官能化CdS量子点（QDs）。选择CdS量子点作为ECL受体，而将双（2,2'-联吡啶）-（5-氨基菲咯啉）钌双（六氟磷酸盐）（Ru-NH ₂）用作ECL受体。Ru-NH ₂通过CdS QDs共价偶联到表面重氮盐化学反应形成CdS-Ru纳米颗粒。ECL共振能量转移（ECL-RET）在CdS-钌纳米颗粒的内部发生，并从硫化镉-钌纳米颗粒在两个正电位在三-的存在下，得到强ECL排放Ñ-丙胺，在过氧二硫酸盐存在下处于负电位。此外，作为概念证明，适体的出色识别能力和CdS-Ru纳米颗粒的良好ECL行为相结合，表明在不同的ECL测量条件下，很容易实现两种灵敏的ECL方法检测凝血酶检测限为0.6 pM和0.7 pM。这项工作表明，具有分子内ECL-RET的CdS-Ru纳米粒子是灵敏检测靶标的良好ECL发光体，这在生物测定具有光谱分辨和潜在分辨可能性的多种测定中很有希望。

更新日期：2019-12-12

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