Deep vein thrombosis (DVT) is a common and lethal complication of surgery. In the clinic, thrombolytic drugs are primarily used for treating DVT. However, the utilization of thrombolytic drugs is limited due to the risk of urokinase (UK)-related hemorrhagic complications. In this paper, a binary eutectic phase-change fatty acid composed of lauric acid and stearic acid was used to block the pores of gold-mesoporous silica core–shell nanoparticles, so as to deliver thrombolytic drugs. The eutectic mixture has a well-defined melting point at 39.2 °C, which can be used as a biocompatible phase-change material for hyperthermia-triggered drug release. The prepared system presents remarkable photothermal effects due to the gold nanoparticles and quick drug release in response to near-infrared irradiation (NIR). In addition, localized hyperthermia could also enhance the lysis of the thrombus. The thrombolytic effect of this system was evaluated in vitro and in vivo. Herein, a rabbit femoral vein thrombosis model was first built for imitating thrombolysis in vivo. The B-ultrasound was then used to monitor the changes in the thrombus after treatment. The results indicated that the reported system could be potentially used to deliver thrombotic drugs in the clinic.

中文翻译：

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热疗触发的UK释放用于深静脉血栓形成治疗的纳米载体†

深静脉血栓形成（DVT）是一种常见且致命的手术并发症。在临床上，溶栓药主要用于治疗DVT。但是，由于存在尿激酶（UK）相关的出血并发症的风险，溶栓药的使用受到限制。在本文中，由月桂酸和硬脂酸组成的二元共晶相变脂肪酸被用来阻塞金介孔二氧化硅核-壳纳米粒子的孔，从而提供溶栓药物。低共熔混合物在39.2°C时具有明确的熔点，可用作热触发药物释放的生物相容性相变材料。制备的系统由于金纳米颗粒和响应近红外辐射（NIR）的快速药物释放而呈现出显着的光热效应。此外，局部热疗还可以增强血栓的溶解。评价了该系统的溶栓作用体外和体内。本文中，首先建立了兔股静脉血栓形成模型以模拟体内的血栓溶解。然后使用B超检查来监测治疗后血栓的变化。结果表明，所报告的系统可潜在地用于在临床中输送血栓性药物。