A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment.,Journal of Materials Chemistry B

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A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-01-14 , DOI: 10.1039/c9tb02453k
Yue Wang ₁ , Xiaoyan Wang ₂ , Li Zhang ₁ , Yan Huang ₂ , Liyan Bi ₃ , Changjun Lv ₃ , Lingxin Chen ₄

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Tumor resistance and drug-induced nephrotoxicity pose great challenges to the clinical treatment of tumors, and they also limit the clinical application of oncology drugs. Finding an effective adjuvant, which can sensitize tumor treatment, is an effective method for tumor treatment. Here, we developed a ratiometric fluorescent probe, TP-Tfs, for superoxide anion (O2˙-) detection in living cells and in vivo during the process of tumor treatment for the first time. TP-Tfs with simple synthesis steps and high yields can detect O2˙- sensitively and selectively, and the detection limit was determined to be 37 nM. Using TP-Tfs, we found that cis-diaminodichloroplatinum(ii) (DDP) was effective in treating tumors by inducing O2˙- burst. Curcumin (cum) can sensitize tumor treatment effectively by inducing more severe O2˙- burst. These results indicated that the probe TP-Tfs was a promising candidate for drug screening and tumor treatment evaluation.

中文翻译：

一种比例荧光探针，用于检测肿瘤治疗过程中的内源性生物信号分子超氧阴离子和生物成像。

肿瘤抗性和药物诱导的肾毒性对肿瘤的临床治疗提出了巨大的挑战，并且它们也限制了肿瘤药物的临床应用。寻找可以使肿瘤治疗敏感的有效佐剂是治疗肿瘤的有效方法。在这里，我们首次开发了一种比例荧光探针TP-Tfs，用于在肿瘤治疗过程中检测活细胞和体内的超氧阴离子（O2 ^-）。合成步骤简单，收率高的TP-Tfs可以灵敏，选择性地检测O2 +-，检测限为37 nM。使用TP-Tfs，我们发现顺式-二氨基二氯铂（ii）（DDP）通过诱导O2 +爆发可有效治疗肿瘤。姜黄素（cum）可以通过诱导更严重的O2 +爆发来有效地使肿瘤治疗敏感。

更新日期：2020-02-13

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