Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates,Chemical Science

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Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates
Chemical Science ( IF 7.6 ) Pub Date : 2020/01/02 , DOI: 10.1039/c9sc05656d
Yugang Bai _{1,

2,

3,

4,

5} , Hang Xing _{1,

2,

3,

4,

5} , Yunhao Bai _{1,

2,

3,

4} , Li Huey Tan _{1,

2,

3,

4} , Kevin Hwang _{1,

2,

3,

4} , Ji Li _{1,

2,

3,

4} , Yi Lu _{1,

2,

3,

4,

6} , Steven C. Zimmerman _{1,

2,

3,

4}

Affiliation

DNA–nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we report a novel, bottom-up approach for the synthesis of DNA–nanoparticle conjugates, based on ring-opening metathesis polymerization (ROMP), intramolecular crosslinking, and template synthesis. Using size, valence, and elemental composition as three independent synthetic parameters, various conjugates can be obtained using a facile and universal procedure. Examples are given to show the usefulness of these conjugates as sensing probes, building blocks for self-assembly, and as model particles for structure–property relationship studies.

中文翻译：

DNA-纳米粒子结合物合成中对大小，化合价和元素组成的独立控制

DNA-纳米粒子共轭物已被广泛用于传感，成像和作为设备的组成部分。然而，它们的合成仍然相对复杂并且基于经验，经常需要针对不同大小，化合价和元素组成的结合物的专门方案。在这里，我们报告了一种基于开环复分解聚合（ROMP），分子内交联和模板合成的，新颖的，自下而上的DNA-纳米粒子共轭物合成方法。使用大小，化合价和元素组成作为三个独立的合成参数，可以使用简便而通用的方法获得各种缀合物。实例显示了这些缀合物作为传感探针，自组装的构建基块以及作为结构-性质关系研究的模型粒子的有用性。

更新日期：2020-02-13

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