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Androgen deprivation therapy plus salvage radiotherapy after prostatectomy.
The Lancet Oncology ( IF 41.6 ) Pub Date : 2020-01-01 , DOI: 10.1016/s1470-2045(19)30730-2
Pirus Ghadjar 1 , Thomas Wiegel 2
Affiliation  

We read with interest the article by Carrie and colleagues in The Lancet Oncology describing the long-term outcomes of the GETUG-AFU 16 trial. After a median follow-up of 112 months (IQR 102–123), metastasis-free survival was improved after 6 months of androgen deprivation therapy combined with salvage radiation therapy versus salvage radiotherapy alone in patients with biochemically recurrent prostate cancer without persisting prostate-specific antigen after radical prostatectomy (hazard ratio 0·73, 95% CI 0·54–0·98; p=0·0339). Patients were grouped by risk (of biological or metastatic recurrence or prostate cancer-related death, according to a combination of several risk factors (GETUG group criteria); however, metastasis-free survival did not differ between low-risk and high-risk subgroups.

中文翻译:

前列腺切除术后雄激素剥夺疗法加抢救放疗。

我们感兴趣地阅读了Carrie及其同事在《柳叶刀肿瘤学》上的文章,该文章描述了GETUG-AFU 16试验的长期结果。在中位随访112个月(IQR 102-123)后,对于生化复发性前列腺癌患者且未坚持前列腺特异性治疗的患者,雄激素剥夺治疗联合挽救放疗相比单独进行挽救放疗6个月后,无转移生存率得到改善前列腺癌根治术后的抗原(危险比0·73,95%CI 0·54-0·98; p = 0·0339)。根据多种风险因素(GETUG组标准)的组合,将患者按风险(生物或转移性复发或前列腺癌相关死亡)分组;但是,低风险和高风险亚组的无转移生存率无差异。
更新日期:2020-01-04
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