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A sensitive nanocomposite design via carbon nanotube and silver nanoparticles: Selective probing of Emedastine Difumarate.
Journal of Pharmaceutical and Biomedical Analysis ( IF 3.1 ) Pub Date : 2020-01-03 , DOI: 10.1016/j.jpba.2020.113096 Hamideh Imanzadeh 1 , Nurgul K Bakirhan 2 , Biuck Habibi 3 , Sibel A Ozkan 4
Journal of Pharmaceutical and Biomedical Analysis ( IF 3.1 ) Pub Date : 2020-01-03 , DOI: 10.1016/j.jpba.2020.113096 Hamideh Imanzadeh 1 , Nurgul K Bakirhan 2 , Biuck Habibi 3 , Sibel A Ozkan 4
Affiliation
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In this study, a novel and sensitive nanocomposite of carboxylate-functionalized multiwalled carbon nanotube (COOH-fMWCNT) and silver nanoparticles (AgNPs) was fabricated and used to modify a glassy carbon electrode (GCE) by a simple drop casting method. Modified electrode was then applied for selective determination of emedastine difumarate (EDD). The COOH-fMWCNT/AgNPs nanocomposite was characterized by electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and cyclic voltammetry (CV). EDD showed two oxidation peaks at 0.634 and 1.2 V on the GCE surface. CV results of COOH-fMWCNT/AgNPs/GCE displayed superior electrocatalytic performance in terms of anodic peak current of EDD when compared to AgNPs/GCE, MWCNT/GCE, and COOH-fMWCNT/GCE. The experimental conditions such as effect of pH, supporting electrolyte, effect of accumulation time and potential, scan rate were optimized for getting intense current signals of the target analyte. Under optimized conditions, COOH-fMWCNT/AgNPs/GCE showed a linear current response for oxidation of EDD in the range of 1.0 × 10-7-1.0 × 10-4 M, with a limit of detection (LOD) and quantification (LOQ) of 5.25 nM, 15.9 nM, respectively, in 0.1 M phosphate buffer solution at pH 2.0 using differential pulse adsorptive stripping voltammetry technique. The proposed method was successfully applied for determination of EDD in pharmaceutical dosage form. Satisfactory recovery percentages were achieved from eye drop sample with acceptable RSD values (less than 2 %). Furthermore, the reproducibility, stability and repeatability of the modified electrode were studied.
中文翻译：
通过碳纳米管和银纳米颗粒进行灵敏的纳米复合材料设计：富马酸依马斯丁的选择性探测。
在这项研究中，一种新颖而灵敏的羧酸盐官能化多壁碳纳米管（COOH-fMWCNT）和银纳米颗粒（AgNPs）纳米复合材料，并通过简单的滴铸法用于修饰玻璃碳电极（GCE）。然后将修饰的电极用于富马酸艾司他汀（EDD）的选择性测定。COOH-fMWCNT / AgNPs纳米复合材料的特征在于电化学阻抗谱（EIS），扫描电子显微镜（SEM），能量色散X射线光谱（EDX）和循环伏安法（CV）。EDD在GCE表面显示0.634和1.2 V处的两个氧化峰。与AgNPs / GCE，MWCNT / GCE和COOH-fMWCNT / GCE相比，COOH-fMWCNT / AgNPs / GCE的CV结果在EDD的阳极峰值电流方面显示出优异的电催化性能。为获得目标分析物的强电流信号，对诸如pH值，支持电解质，累积时间和电势，扫描速率等实验条件进行了优化。在优化条件下，COOH-fMWCNT / AgNPs / GCE对EDD氧化的线性电流响应为1.0×10-7-1.0×10-4 M，检测限（LOD）和定量限（LOQ）使用微分脉冲吸附溶出伏安法在pH 2.0的0.1 M磷酸盐缓冲溶液中分别提取5.25 nM和15.9 nM的溶液。该方法成功用于药物剂型中EDD的测定。从具有可接受的RSD值（小于2％）的眼药水样品中获得令人满意的回收率。此外，可重复性
更新日期：2020-01-04
中文翻译：
通过碳纳米管和银纳米颗粒进行灵敏的纳米复合材料设计：富马酸依马斯丁的选择性探测。
在这项研究中，一种新颖而灵敏的羧酸盐官能化多壁碳纳米管（COOH-fMWCNT）和银纳米颗粒（AgNPs）纳米复合材料，并通过简单的滴铸法用于修饰玻璃碳电极（GCE）。然后将修饰的电极用于富马酸艾司他汀（EDD）的选择性测定。COOH-fMWCNT / AgNPs纳米复合材料的特征在于电化学阻抗谱（EIS），扫描电子显微镜（SEM），能量色散X射线光谱（EDX）和循环伏安法（CV）。EDD在GCE表面显示0.634和1.2 V处的两个氧化峰。与AgNPs / GCE，MWCNT / GCE和COOH-fMWCNT / GCE相比，COOH-fMWCNT / AgNPs / GCE的CV结果在EDD的阳极峰值电流方面显示出优异的电催化性能。为获得目标分析物的强电流信号，对诸如pH值，支持电解质，累积时间和电势，扫描速率等实验条件进行了优化。在优化条件下，COOH-fMWCNT / AgNPs / GCE对EDD氧化的线性电流响应为1.0×10-7-1.0×10-4 M，检测限（LOD）和定量限（LOQ）使用微分脉冲吸附溶出伏安法在pH 2.0的0.1 M磷酸盐缓冲溶液中分别提取5.25 nM和15.9 nM的溶液。该方法成功用于药物剂型中EDD的测定。从具有可接受的RSD值（小于2％）的眼药水样品中获得令人满意的回收率。此外，可重复性
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