A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. Pertinent clinical data were collected. Eight (8) carbamazepine-induced SJS/TEN cases and 32 tolerant controls were recruited. Genomic DNA was extracted from the saliva samples and genotyping was performed by employing allele-specific polymerase chain reaction. Data were analyzed using the Fisher's exact test, Mann-Whitney U test, univariate logistic regression, and multivariate logistic regression. Single allele association analysis was done. The strength of association was expressed as odds ratio with 95% confidence interval. Positive predictive value, negative predictive value, sensitivity, and specificity were computed. Of all the alleles tested, the HLA-B75 serotype (p = 0.007, OR = 23.25, 95% CI = 2.33-232.21) and HLA-B*15:21 (p = 0.026, OR = 7.53, 95% CI = 1.27-44.79) were significantly associated with carbamazepine-induced SJS/TEN. The HLA-B75 serotype or HLA-B*15:21 allele may be used as a genetic risk assessment prior to prescription for prevention of carbamazepine-induced SJS/TEN in Filipino patients.

中文翻译：

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卡马西平诱导的史蒂文斯-约翰逊综合征/毒性表皮坏死溶解与菲律宾患者的HLA-B75血清型或HLA-B * 15：21等位基因相关。

进行了一项病例对照研究，以调查菲律宾患者中卡马西平诱导的SJS / TEN与HLA-A等位基因，HLA-B等位基因（包括HLA-B * 15：02和HLA-B75血清型）的关联。回顾性检查病历。收集相关的临床数据。招募了八（8）个卡马西平诱导的SJS / TEN病例和32个耐受性对照。从唾液样品中提取基因组DNA，并通过等位基因特异性聚合酶链反应进行基因分型。使用Fisher精确检验，Mann-Whitney U检验，单变量logistic回归和多元logistic回归分析数据。单等位基因关联分析完成。关联强度表示为具有95％置信区间的比值比。正预测值，负预测值，敏感性，和特异性进行了计算。在所有测试的等位基因中，HLA-B75血清型（p = 0.007，OR = 23.25，95％CI = 2.33-232.21）和HLA-B * 15：21（p = 0.026，OR = 7.53，95％CI = 1.27 -44.79）与卡马西平诱导的SJS / TEN显着相关。HLA-B75血清型或HLA-B * 15：21等位基因可在预防卡马西平诱导的菲律宾患者SJS / TEN处方前用作遗传风险评估。