Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.,Biomaterials Science

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Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-01-22 , DOI: 10.1039/c9bm01089k
Cheirmadurai Kalirajan ₁ , Thanikaivelan Palanisamy ₁

Affiliation

The existence of diabetes and microbial infection in burn wounds makes the healing process more complex. Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection. The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen. The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies. Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls. Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing. The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.

中文翻译：

二氧化硅微球-间苯二酚复合材料包埋的胶原蛋白支架可为I型糖尿病和非糖尿病大鼠的慢性感染烧伤提供无疤痕的愈合。

烧伤伤口中存在糖尿病和微生物感染，使愈合过程更加复杂。本文中，我们合成了一种基于胶原蛋白的混合支架，该支架中掺入了二氧化硅-间苯二酚复合物，并与氧化的胡芦巴籽多糖交联，以刺激I型糖尿病和微生物感染的慢性伤口的无疤痕愈合。杂种支架的光谱分析揭示了胶原的化学和结构完整性。通过细胞相容性和血液相容性研究显示，杂种支架适用于体内组织再生。将支架分别应用于由慢性感染的烧伤创面和相应对照诱导的糖尿病白化病大鼠。从混合支架处理的动物组收集的肉芽组织的组织学和免疫组织化学分析显示，血管生成，再上皮化和TGF-β3表达得到改善，最终导致无疤痕的伤口愈合。结果证实，所制备的杂合胶原支架可用于慢性烧伤创面的有效无疤痕创面愈合。

更新日期：2020-03-19

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