Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

中文翻译：

---

神经型细胞在多尺度有序胶原-二氧化硅bionanocomposites上的分化。

细胞响应生物物理和生化信号。我们从胶原蛋白和二氧化硅颗粒开发了一种复合长丝，将其与胶原蛋白相互作用和/或提出了层粘连蛋白表位（IKVAV），这对于细胞基质粘附和信号转导至关重要。这将脚手架和信号传导结合在一起，表明胶原蛋白组织的局部调节增强了细胞分化。