Paper-based microfluidic device was designed with wax-printing to combine potentiometric, fluorimetric and colorimetric detection zones. This newly developed trimodal paper chip has been used for on-site determination of ketamine hydrochloride (KET) as a date rape drug in beverages. The device employed polyaniline nano-dispersion as conducting polymer in ion sensing paper electrodes designed to fit USB plug connector. Carbon dots-gold nanoparticles and cobalt thiocyanate were used in fluorescence and color detection zones, respectively. Cellular phone's camera facilitated the on-site fluorimetric and color detection. The implemented trimodal detection system exhibited specificity for KET detection in the presence of several other beverage interferences i.e., biogenic amines. This innovative sensor brings together analytical figures of merit for effective KET detection in single aliquot of spiked beverages. The proposed paper-based chip also fulfils WHO criteria for point-of-care devices posing the proposed trimodal paper device as an active part for rapid, on-site drug diagnostics and to be applied further for other similar drugs.

中文翻译：

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一种基于纸基微流控装置的新型三模态系统，用于现场检测约会强奸药物“氯胺酮”

纸基微流体装置采用蜡印设计，以结合电位、荧光和比色检测区。这种新开发的三峰纸芯片已用于现场测定盐酸氯胺酮 (KET) 作为饮料中的椰枣药物。该设备采用聚苯胺纳米分散体作为离子传感纸电极中的导电聚合物，设计用于安装 USB 插头连接器。碳点-金纳米粒子和硫氰酸钴分别用于荧光和颜色检测区。手机的摄像头促进了现场荧光和颜色检测。实施的三峰检测系统在存在几种其他饮料干扰（即生物胺）的情况下表现出对 KET 检测的特异性。这种创新的传感器汇集了分析品质因数，可在单份加标饮料中进行有效的 KET 检测。拟议的纸质芯片还符合 WHO 的床旁设备标准，将拟议的三模式纸质设备作为快速现场药物诊断的积极部分，并进一步应用于其他类似药物。