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4-Nonylphenol and 4-tert-octylphenol induce anxiety-related behaviors through alternation of 5-HT receptors and transporters in the prefrontal cortex.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-01-03 , DOI: 10.1016/j.cbpc.2020.108701
Jiao Yang 1 , Qingyi Huang 1 , Huan Liu 1 , Xiong Zhou 1 , Zhuoquan Huang 1 , Quansheng Peng 2 , Chunhong Liu 1
Affiliation  

Environmental endocrine disruptors 4-nonylphenol (NP) and 4-tert-octylphenol (OP) may cast huge harm to human health. We used a rat model to observe the influence of NP or/and OP exposure on anxiety-related behaviors and the underlying mechanisms. Eighty male Sprague-Dawley (SD) rats were randomly divided into 10 groups: control group (corn oil), NP groups [30, 90, 270 mg/kg], OP groups [40, 120, 360 mg/kg] and NO groups [(mixed with the corresponding NP, OP alone exposed low, medium and high dose according to the natural environment exists NP:OP = 4:1]. The rats were orally administered every other day for 30 days. The neurobehaviors of rats were evaluated by open-field test (OFT) and elevated plus-maze test (EPM), and the concentrations of 5-HT, monoamine oxidase (MAOA), serotonin transporter (SERT), vesicular monoamine transporter 2 (VAMT2), 5-hydroxytryptamine 1A (5-HT1A), 5-hydroxytryptamine 2A (5-HT2A),and 5-hydroxytryptamine 2C (5-HT2C) in the rat prefrontal cortex were analyzed by ELISA. OFT and EPM tests showed that NP or/and OP exposure induced anxiety-related behaviors in rats. 5-HT levels were significantly increased compared with the control group. The levels of MAOA, SERT, VAMT2, 5-HT1A, 5-HT2A, and 5-HT2C in the prefrontal cortex reduced in different degrees by high-doses NP or/and OP exposure. In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT1A, 5-HT2A, and 5-HT2C.

中文翻译:

4-壬基苯酚和4-叔辛基苯酚通过前额叶皮层中5-HT受体和转运蛋白的交替诱导焦虑相关行为。

环境内分泌干扰物4-壬基苯酚(NP)和4-叔辛基苯酚(OP)可能对人体健康造成巨大危害。我们使用大鼠模型观察NP或/和OP暴露对焦虑相关行为及其潜在机制的影响。将80只雄性Sprague-Dawley(SD)大鼠随机分为10组:对照组(玉米油),NP组[30、90、270 mg / kg],OP组[40、120、360 mg / kg]和NO组[(与相应的NP混合,根据自然环境,OP分别暴露于低,中,高剂量下存在NP:OP = 4:1]。每隔一天口服大鼠30天。大鼠的神经行为为通过露天试验(OFT)和高迷宫试验(EPM)进行了评估,以及5-HT,单胺氧化酶(MAOA),5-羟色胺转运蛋白(SERT),水泡单胺转运蛋白2(VAMT2)的浓度,用ELISA法分析大鼠前额叶皮层中的5-羟色胺1A(5-HT1A),5-羟色胺2A(5-HT2A)和5-羟色胺2C(5-HT2C)。OFT和EPM测试表明,NP或OP暴露可引起大鼠焦虑相关行为。与对照组相比,5-HT水平显着升高。大剂量NP或/和OP暴露可以使前额叶皮层中的MAOA,SERT,VAMT2、5-HT1A,5-HT2A和5-HT2C的含量不同程度地降低。总之,暴露于NP或/和OP可能通过改变5-HT分解酶MAOA,转运蛋白SERT和VMAT2以及5-HT受体5-HT1A的表达来调节神经递质5-HT的水平,从而引起大鼠焦虑相关行为。 5-HT2A和5-HT2C。ELISA法检测大鼠前额叶皮层中5-羟色胺2A(5-HT2A)和5-羟色胺2C(5-HT2C)。OFT和EPM测试表明,NP或OP暴露可引起大鼠焦虑相关行为。与对照组相比,5-HT水平显着升高。大剂量NP或/和OP暴露可以使前额叶皮层中的MAOA,SERT,VAMT2、5-HT1A,5-HT2A和5-HT2C的含量不同程度地降低。总之,暴露于NP或/和OP可能通过改变5-HT分解酶MAOA,转运蛋白SERT和VMAT2以及5-HT受体5-HT1A的表达来调节神经递质5-HT的水平,从而引起大鼠焦虑相关行为。 5-HT2A和5-HT2C。ELISA法检测大鼠前额叶皮层中5-羟色胺2A(5-HT2A)和5-羟色胺2C(5-HT2C)。OFT和EPM测试表明,NP或OP暴露可引起大鼠焦虑相关行为。与对照组相比,5-HT水平显着升高。大剂量NP或/和OP暴露可以使前额叶皮层中的MAOA,SERT,VAMT2、5-HT1A,5-HT2A和5-HT2C的含量不同程度地降低。总之,暴露于NP或/和OP可能通过改变5-HT分解酶MAOA,转运蛋白SERT和VMAT2以及5-HT受体5-HT1A的表达来调节神经递质5-HT的水平,从而引起大鼠焦虑相关行为。 5-HT2A和5-HT2C。与对照组相比,5-HT水平显着升高。大剂量NP或/和OP暴露可以使前额叶皮层中的MAOA,SERT,VAMT2、5-HT1A,5-HT2A和5-HT2C的含量不同程度地降低。总之,暴露于NP或/和OP可能通过改变5-HT分解酶MAOA,转运蛋白SERT和VMAT2以及5-HT受体5-HT1A的表达来调节神经递质5-HT的水平,从而引起大鼠焦虑相关行为。 5-HT2A和5-HT2C。与对照组相比,5-HT水平显着升高。大剂量NP或/和OP暴露可以使前额叶皮层中的MAOA,SERT,VAMT2、5-HT1A,5-HT2A和5-HT2C的含量不同程度地降低。总之,暴露于NP或/和OP可能通过改变5-HT分解酶MAOA,转运蛋白SERT和VMAT2以及5-HT受体5-HT1A的表达来调节神经递质5-HT的水平,从而引起大鼠焦虑相关行为。 5-HT2A和5-HT2C。
更新日期:2020-01-04
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