Concise catalytic asymmetric total syntheses of aromatic sesquiterpenes, naturally occurring (+)-ar-macrocarpene (1) and unnatural (−)-ar-macrocarpene (ent-1) have been featured (6 steps, ∼60–61% overall yields) from commercially available 4,4-dimethylcyclohex-2-enone 16. The enantioenriched allyl alcohol 12 is obtained from catalytic enantioselective reduction of enone 13b using Corey-Bakshi-Shibata catalyst in 93% ee, which is found to be the key intermediate. A highly diastereoselective hydrogenation of enantioenriched allyl alcohol 12 (10.3:1 dr) followed by deoxygenation completes straightforward access to (+)-ar-macrocarpene (1) and (−)-ar-macrocarpene (ent-1).

精巧地合成了芳香倍半萜的催化不对称全合成，包括天然（+）- ar-大麦烯（1）和非天然（-）- ar-大麦烯（ent - 1）（6步，总产率约60-61％）从市售的4,4-二甲基环己-2-烯酮16。通过使用Corey-Bakshi-Shibata催化剂在93％ee中催化烯酮13b的催化对映选择性还原获得对映体富集的烯丙醇12，发现其为关键中间体。对映体富集的烯丙醇的高度非对映选择性氢化12（10.3：1 dr），然后进行脱氧操作，可以轻松地直接访问（+）- ar-大麦烯（1）和（-）- ar-大麦烯（ent - 1）。