Abstract In this work, core-shell electrospun mats based on poly (lactic acid) (PLA) and polyvinyl alcohol (PVA) were developed as novel curcumin release materials. The effect of the incorporation of cellulose nanocrystals (CNN) in the PLA shell structure on structural, thermal and curcumin release were studied. A phenomenological mass transfer model was used to correlate the experimental release kinetic data as well as the structural and thermal characterization of the electrospun mats. Curcumin distribution coefficients (KP/SA) values for core-shell electrospun PLA/PVA mats were higher than KP/SA values of uniaxial active PLA. Modelling analysis evidenced PLA/PVA coaxial structures slowed down the effective diffusion coefficients of curcumin, and this value notoriously decreased by the incorporation of CNC in the PLA shell matrix due to the tortuous path created through the PLA matrix.

中文翻译：

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设计具有单核和核壳结构的活性电纺垫以实现不同的姜黄素释放动力学

摘要 在这项工作中，基于聚乳酸 (PLA) 和聚乙烯醇 (PVA) 的核壳电纺毡被开发为新型姜黄素释放材料。研究了在 PLA 壳结构中掺入纤维素纳米晶体 (CNN) 对结构、热和姜黄素释放的影响。现象学传质模型用于关联实验释放动力学数据以及电纺垫的结构和热特性。核壳电纺 PLA/PVA 垫的姜黄素分布系数 (KP/SA) 值高于单轴活性 PLA 的 KP/SA 值。建模分析表明 PLA/PVA 同轴结构减慢了姜黄素的有效扩散系数，