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Bioactive chemical constituents from the seed testa of Vernicia fordii as potential neuroinflammatory inhibitors
Phytochemistry ( IF 3.2 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.phytochem.2019.112233 Gang Chen 1 , Weihong Zhao 1 , Yang Li 1 , Di Zhou 1 , Jing Ding 1 , Bin Lin 2 , Wei Li 3 , Yanqiu Yang 4 , Jingyu Liu 4 , Yue Hou 4 , Ning Li 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.phytochem.2019.112233 Gang Chen 1 , Weihong Zhao 1 , Yang Li 1 , Di Zhou 1 , Jing Ding 1 , Bin Lin 2 , Wei Li 3 , Yanqiu Yang 4 , Jingyu Liu 4 , Yue Hou 4 , Ning Li 1
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Eight previously undescribed and 15 known components, including six neolignans, two monolignan, three sesquineolignans, three dineolignans, eight phenylpropanoids, and one steroid were identified from the seed testa of Vernicia fordii. Their structures were established based on the comprehensive analysis of NMR and ECD data. The anti-neuroinflammatory effects of the isolates were evaluated through nitrite assays in LPS-induced BV2 cells. As a result, isodiverniciasin A, diverniciasin B, diverniciasin C, isoprincepin, princepin, 3, 3'-bisdemethylpinoresinol, (+)-7-epi-sesamin-dicatechol, isoamericanin A, americanin B, 7S, 8R-americanin D, 4-hydroxyl cinnamic aldehyde, 3-hydroxyl-4-methoxyl cinnamic aldehyde and 24R-6β-hydroxy-24- ethylcholest-4-en-3-one exhibited significant inhibitory effects on nitric oxide (NO) production and isoprincepin, princepin, americanin B, and 4-hydroxyl cinnamic aldehyde suppressed the overexpression of inflammatory cytokines TNF-α, IL-1β, and IL-6 in over-activated microglia. The results suggested that bioactive ingredients from the seed testa of V. fordii can serve as potential therapeutic agents for neurodegenerative diseases.
中文翻译：
来自 Vernicia fordii 种子种皮的生物活性化学成分作为潜在的神经炎症抑制剂
从 Vernicia fordii 的种皮中鉴定出 8 种以前未描述的成分和 15 种已知成分，包括 6 种新木脂素、2 种单木脂素、3 种倍半木脂素、3 种双木脂素、8 种苯丙素和一种类固醇。它们的结构是基于对 NMR 和 ECD 数据的综合分析而建立的。通过 LPS 诱导的 BV2 细胞中的亚硝酸盐测定评估分离物的抗神经炎症作用。因此，异毛虫素 A、毛虫素 B、毛虫素 C、isoprincepin、princepin、3, 3'-双去甲基松脂醇、(+)-7-epi-芝麻素-dicchol、isoamericanin A、americanin B、7S、8R-americanin D、4 -羟基肉桂醛、3-羟基-4-甲氧基肉桂醛和 24R-6β-羟基-24-乙基胆甾醇-4-en-3-one 对一氧化氮 (NO) 的产生和异普林斯平表现出显着的抑制作用，Princepin、Americanin B 和 4-羟基肉桂醛抑制过度活化的小胶质细胞中炎性细胞因子 TNF-α、IL-1β 和 IL-6 的过度表达。结果表明，来自 V. fordii 种皮的生物活性成分可作为神经退行性疾病的潜在治疗剂。
更新日期：2020-03-01
中文翻译：
来自 Vernicia fordii 种子种皮的生物活性化学成分作为潜在的神经炎症抑制剂
从 Vernicia fordii 的种皮中鉴定出 8 种以前未描述的成分和 15 种已知成分，包括 6 种新木脂素、2 种单木脂素、3 种倍半木脂素、3 种双木脂素、8 种苯丙素和一种类固醇。它们的结构是基于对 NMR 和 ECD 数据的综合分析而建立的。通过 LPS 诱导的 BV2 细胞中的亚硝酸盐测定评估分离物的抗神经炎症作用。因此，异毛虫素 A、毛虫素 B、毛虫素 C、isoprincepin、princepin、3, 3'-双去甲基松脂醇、(+)-7-epi-芝麻素-dicchol、isoamericanin A、americanin B、7S、8R-americanin D、4 -羟基肉桂醛、3-羟基-4-甲氧基肉桂醛和 24R-6β-羟基-24-乙基胆甾醇-4-en-3-one 对一氧化氮 (NO) 的产生和异普林斯平表现出显着的抑制作用，Princepin、Americanin B 和 4-羟基肉桂醛抑制过度活化的小胶质细胞中炎性细胞因子 TNF-α、IL-1β 和 IL-6 的过度表达。结果表明，来自 V. fordii 种皮的生物活性成分可作为神经退行性疾病的潜在治疗剂。
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