INTRODUCTION Bisphenol F (BPF) and bisphenol S (BPS) are chemical substitutes for, and may have similar physiological effects to, bisphenol A (BPA). Bisphenols provoke endocrine disorders and are cytotoxic, oxidize hemoglobin, and induce morphological changes in human red blood cells (RBC). It is more sensitive to changes in the RBC number and hemoglobin (Hb) level during pregnancy. Therefore, we investigated the effects of bisphenols (BPs) and their substitute compounds on hemopoiesis and the serum biochemical parameters of pregnant women. METHODS The study population comprised 196 pregnant women from the MAKE cohort study, recruitment for which occurred from 2017 to 2019. We measured the levels of BPA, BPF and BPS in urine samples and collected data on socioeconomic, lifestyle, and environmental factors at visits to the hospital. The associations between the levels of the three BPs and biochemical parameters were analyzed by multiple linear regression. RESULTS The geometric mean urinary concentrations of specific gravity adjusted BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. There was a significant negative association between the urinary concentration of BPA and the Hb level (β = -0.5, p = 0.02). After stratifying by the median concentrations of the three BPs, the maternal urinary BPA level had a significantly negative effect on the RBC count, HB level, and hematocrit in the high BPA concentration group (RBC, β = - 0.5, p = 0.001; Hb, β = -1.4, p = 0.002; Hct, β = -5.0, p = 0.001). CONCLUSIONS BPA has a harmful effect on hemato-biochemical changes that occur during pregnancy. Further studies should investigate the relation between widespread exposure to bisphenols and effects on human health.

中文翻译：

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韩国孕妇的尿双酚A及其类似物和血液生化改变。

简介双酚F（BPF）和双酚S（BPS）是双酚A（BPA）的化学替代品，并且可能具有与之相似的生理作用。双酚引起内分泌失调，具有细胞毒性，氧化血红蛋白并诱导人红细胞（RBC）发生形态变化。在怀孕期间它对RBC数和血红蛋白（Hb）水平的变化更敏感。因此，我们调查了双酚（BPs）及其替代化合物对孕妇的造血和血清生化指标的影响。方法该研究人群包括196位来自MAKE队列研究的孕妇，该研究于2017年至2019年招募。我们测量了尿液样本中的BPA，BPF和BPS水平，并在就诊时收集了社会经济，生活方式和环境因素的数据医院 通过多元线性回归分析了三个BP的水平与生化参数之间的关联。结果经比重调整的BPA，BPF和BPS的几何平均尿浓度分别为2.1、0.2和0.1μg/ L。BPA的尿液浓度与Hb水平之间存在显着的负相关（β= -0.5，p = 0.02）。按三个BP的中位数浓度分层后，高BPA浓度组中的孕妇尿BPA水平对RBC计数，HB水平和血细胞比容有显着负面影响（RBC，β=-0.5，p = 0.001； Hb ，β= -1.4，p = 0.002； Hct，β= -5.0，p = 0.001）。结论BPA对怀孕期间发生的血液生化变化有有害影响。