The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds.,Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer ( IF 9.7 ) Pub Date : 2020-01-03 , DOI: 10.1016/j.bbcan.2020.188338
Fabrizio Fontana ₁ , Michela Raimondi ₁ , Monica Marzagalli ₁ , Alessandro Di Domizio ₂ , Patrizia Limonta ₁

Affiliation

Standard anti-cancer therapies promote tumor growth suppression mainly via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In this setting, the interest in alternative cell death modes has recently increased. Paraptosis is a new form of programmed cell death displaying endoplasmic reticulum (ER) and/or mitochondria dilation, generally due to proteostasis disruption or redox and ion homeostasis alteration. Recent studies have highlighted that several natural compounds can trigger paraptosis in different tumor cell lines. Here, we review the molecular mechanisms underlying paraptotic cell death, as well as the natural products inducing this kind of cell death program. A better understanding of paraptosis should facilitate the development of new therapeutic strategies for cancer prevention and treatment.

中文翻译：

截瘫在肿瘤细胞生物学中的新兴作用：天然化合物预防和治疗癌症的观点。

标准的抗癌疗法主要通过诱导凋亡来促进肿瘤生长抑制。然而，在大多数情况下，癌细胞具有逃脱凋亡性细胞死亡的能力，从而对当前的治疗产生抵抗力。在这种情况下，最近人们对替代细胞死亡模式的兴趣增加了。截瘫是一种新的程序性细胞死亡形式，表现出内质网（ER）和/或线粒体扩张，通常是由于蛋白稳态破坏或氧化还原和离子稳态改变引起的。最近的研究强调了几种天然化合物可以在不同的肿瘤细胞系中触发截瘫。在这里，我们审查了隐性细胞死亡的分子机制，以及诱导这种细胞死亡程序的天然产物。

更新日期：2020-04-20

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