Eosinophilic esophagitis (EoE) is an eosinophil-rich, TH2 antigen-mediated disease of increasing pediatric and adult worldwide prevalence. Diagnosis requires greater than or equal to 15 eosinophils per high-power field on light microscopy. Symptoms reflect esophageal dysfunction, and typical endoscopic features include linear furrows, white plaques, and concentric rings. Progressive disease leads to pathologic tissue remodeling, with ensuing esophageal rigidity and loss of luminal diameter caused by strictures. Therapies include proton pump inhibitors, elimination diets, and topical corticosteroids. Effective treatment can reverse tissue fibrosis in some patients, as well as decrease the rate of food impactions. Esophageal dilation might be required to increase luminal patency. The chronic nature of EoE necessitates long-term therapy to avoid disease recurrence and complications. This review serves the function of providing the current state-of-the-art diagnostic criteria and disease management for adult and pediatric EoE.

中文翻译：

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嗜酸性食管炎的诊断和治疗。

嗜酸性食管炎（EoE）是一种富含嗜酸性粒细胞的TH2抗原介导的疾病，正在全球范围内引起儿童和成人患病率的上升。在光学显微镜下，每个高倍视野的诊断需要大于或等于15个嗜酸性粒细胞。症状反映出食管功能障碍，典型的内窥镜检查特征包括线性犁沟，白斑和同心环。进行性疾病导致病理组织重塑，随之而来的是食管僵硬和狭窄引起的管腔直径减小。治疗方法包括质子泵抑制剂，消除饮食和局部糖皮质激素。有效的治疗可以逆转某些患者的组织纤维化，并降低食物感染的发生率。可能需要食管扩张以增加管腔通畅性。EoE的慢性性质需要长期治疗，以避免疾病复发和并发症。这项审查的功能是为成人和儿童EoE提供最新的诊断标准和疾病管理。