Low bioavailability and stability of 7,8-dihydroxyflavone (7,8-DHF) hinder its potential application in prevention of humans’ disease. 7,8-DHF loaded nanoliposomes decorated by original, crosslinked and glycosylated lactoferrin (LF) were fabricated. The mean particle size of spherical crosslinked and glycosylated LF coating liposomes were larger than uncoated liposomes with a low polydispersity index, and the former had higher encapsulation efficiency (Above 98%). Crosslinked and glycosylated LF coating liposomes had higher antioxidant activity, storage stability, slow-release ability, bioaccessibility and transepithelial transport compared to free 7,8-DHF and 7,8-DHF loaded liposome. Effective hydrogen bonding between phospholipid and 7,8-DHF, while electrostatic interaction and hydrogen bonding between LF proteins and phospholipid existed. The encapsulated 7,8-DHF was in an amorphous state rather than a crystalline form as detected by differential scanning calorimetry. Collectively, crosslinked or glycosylated LF coating liposomes are promising delivery systems for protecting and transporting 7,8-DHF or other relative bioactive components.

7,8-二羟基黄酮（7,8-DHF）的低生物利用度和稳定性阻碍了其在预防人类疾病中的潜在应用。制备了由原始的，交联的和糖基化的乳铁蛋白（LF）修饰的7,8-DHF负载的纳米脂质体。球形交联和糖基化的LF包衣脂质体的平均粒径要比未包衣的脂质体大，且多分散指数低，前者的包封效率更高（98％以上）。与负载的7,8-DHF和7,8-DHF脂质体相比，交联和糖基化的LF包衣脂质体具有更高的抗氧化活性，储存稳定性，缓释能力，生物可及性和经上皮运输。磷脂与7,8-DHF之间存在有效的氢键结合，而LF蛋白与磷脂之间存在静电相互作用和氢键结合。如通过差示扫描量热法检测到的，包封的7，8-DHF处于非晶态而不是结晶形式。总的来说，交联或糖基化的LF包衣脂质体是用于保护和运输7，8-DHF或其他相对生物活性组分的有希望的递送系统。