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Toward a multi-target multi-channel hyperthermia treatment system: Proof of concept with numerical simulations
International Journal of Heat and Mass Transfer ( IF 5.0 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.ijheatmasstransfer.2019.119257
N. Nizam-Uddin , Wazie M. Abdulkawi , Ibrahim Elshafiey , Abdel-Fattah A. Sheta

Abstract This paper presents electromagnetic therapy system based on a multi-channel approach for targeting multi-locous tumors, for hyperthermia treatment of the head region. This study aims to treat multi-lesions simultaneously. A numerical head phantom is developed to perform an electromagnetic simulation study to quantity specific absorption rate (SAR) accumulation at regions of interest to prove the efficacy of the proposed system. A custom monopole-based applicator array is designed and fabricated to project energy subcarriers of different frequencies toward the head phantom. A modified phase-array tool is invoked as waveform-shaping module to deposit energies coherently at tumor locations. The acquired SAR profiles are utilized to realize the thermal response of the case under study. The accomplished results prove the therapeutic capability of the proposed system by treating tumors of various sizes at different locations simultaneously, thereby adding a degree of freedom to improve the efficacy of hyperthermia treatment.

中文翻译:

迈向多目标多通道热疗系统:数值模拟的概念验证

摘要 本文提出了一种基于多通道方法的电磁治疗系统,用于靶向多部位肿瘤,用于头部区域的热疗。本研究旨在同时治疗多个病变。开发了一种数字头部模型来执行电磁模拟研究,以量化感兴趣区域的特定吸收率 (SAR) 累积,以证明所提出系统的有效性。一个定制的基于单极子的施加器阵列被设计和制造,以将不同频率的能量子载波投射到头部幻影。修改后的相位阵列工具被用作波形整形模块,以在肿瘤位置一致地沉积能量。获取的 SAR 剖面用于实现所研究案例的热响应。
更新日期:2020-04-01
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