![][1] MYC is critical for tumorigenesis, however, to date it remains untargetable. Han and colleagues utilized a pharmacophore-based in silico screening approach to validate in vitro and in vivo small molecules that disrupted MYC/MAX dimerization and DNA binding. Their lead compound

中文翻译：

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近期癌症文献集锦


！[] [1] MYC对于肿瘤发生至关重要，但是迄今为止，它仍然是不可靶向的。Han和同事利用一种基于药效团的计算机模拟筛选方法来验证破坏MYC / MAX二聚体和DNA结合的体外和体内小分子。他们的铅化合物