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Graphene Quantum Dots/Multiwalled Carbon Nanotubes Composite-Based Electrochemical Sensor for Detecting Dopamine Release from Living Cells
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-01-14 , DOI: 10.1021/acssuschemeng.9b06623 Qitong Huang 1, 2 , Xiaofeng Lin 2 , Lili Tong 3 , Qing-Xiao Tong 2
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-01-14 , DOI: 10.1021/acssuschemeng.9b06623 Qitong Huang 1, 2 , Xiaofeng Lin 2 , Lili Tong 3 , Qing-Xiao Tong 2
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Dopamine (DA) is an important neurotransmitter associated with nerve signaling and some diseases. Therefore, it is very significant to detect DA in patients to regulate body function. Compared with other traditional methods, these electrochemical sensors have their intrinsic advantages of high sensitivity, celerity, simplicity, and economy. In this article, a graphene quantum dots/multiwalled carbon nanotubes (GQDs-MWCNTs) composite-based ultrasensitive electrochemical sensor for detecting dopamine (DA) was fabricated. As the carbon nanomaterials, GQDs have large surface areas to improve the conductivity of the electrodes, and the MWCNTs are excellent electrode materials. As expected, the sensor has excellent selectivity of dopamine among other interfering bioanalytes. Under optimum conditions, this electrochemical sensor exhibited maximum performance toward DA determination with good linearity in a broad linear range of 0.005 to 100.0 μM with the detection limit of 0.87 nM (3S/N). Furthermore, this electrochemical sensor was successfully applied for detecting DA in human serum, and it was the first example to measure DA secreted from live PC12 cells with excellent performance.
中文翻译：
基于石墨烯量子点/多壁碳纳米管的复合电化学传感器，用于检测多巴胺从活细胞中的释放
多巴胺（DA）是与神经信号传导和某些疾病相关的重要神经递质。因此，检测患者的DA对调节身体机能具有十分重要的意义。与其他传统方法相比，这些电化学传感器具有高灵敏度，快速，简单和经济的内在优势。本文制备了一种基于石墨烯量子点/多壁碳纳米管（GQDs-MWCNTs）复合材料的多巴胺（DA）超敏电化学传感器。作为碳纳米材料，GQD具有大的表面积以提高电极的导电性，而MWCNT是极好的电极材料。如预期的那样，该传感器在其他干扰生物分析物中具有出色的多巴胺选择性。在最佳条件下 该电化学传感器在0.005至100.0μM的宽线性范围内，检测限为0.87 nM（3S / N），具有良好的线性，在DA测定方面表现出最大的性能。此外，该电化学传感器已成功应用于人体血清中DA的检测，这是第一个以优异的性能检测活PC12细胞分泌的DA的实例。
更新日期：2020-01-15
中文翻译：
基于石墨烯量子点/多壁碳纳米管的复合电化学传感器，用于检测多巴胺从活细胞中的释放
多巴胺（DA）是与神经信号传导和某些疾病相关的重要神经递质。因此，检测患者的DA对调节身体机能具有十分重要的意义。与其他传统方法相比，这些电化学传感器具有高灵敏度，快速，简单和经济的内在优势。本文制备了一种基于石墨烯量子点/多壁碳纳米管（GQDs-MWCNTs）复合材料的多巴胺（DA）超敏电化学传感器。作为碳纳米材料，GQD具有大的表面积以提高电极的导电性，而MWCNT是极好的电极材料。如预期的那样，该传感器在其他干扰生物分析物中具有出色的多巴胺选择性。在最佳条件下 该电化学传感器在0.005至100.0μM的宽线性范围内，检测限为0.87 nM（3S / N），具有良好的线性，在DA测定方面表现出最大的性能。此外，该电化学传感器已成功应用于人体血清中DA的检测，这是第一个以优异的性能检测活PC12细胞分泌的DA的实例。
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