Exploring the Reactivity and Biological Effects of Heteroleptic N-Heterocyclic Carbene Gold(I)-Alkynyl Complexes,European Journal of Inorganic Chemistry

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Exploring the Reactivity and Biological Effects of Heteroleptic N-Heterocyclic Carbene Gold(I)-Alkynyl Complexes
European Journal of Inorganic Chemistry ( IF 2.2 ) Pub Date : 2020-01-03 , DOI: 10.1002/ejic.201901043
Jens Oberkofler _{1,

2,

3} , Brech Aikman ₂ , Riccardo Bonsignore ₂ , Alexander Pöthig ₁ , James Platts ₂ , Angela Casini _{2,

3} , Fritz E. Kühn ₁

Affiliation

Two families of heteroleptic N‐heterocyclic carbene gold(I)‐alkynyl complexes have been synthesized and characterized by different methods. Their reactivity with model thiols has been studied by NMR spectroscopy and DFT calculations. Moreover, preliminary studies on the compounds' reactivity with DNA and antiproliferative effects have been conducted.

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