Atopic dermatitis (AD) is a chronic inflammatory skin disease. A hallmark of AD is dry itchy skin that results from defects in the epidermal barrier function. Aloe vera is used widely to promote general health and is administered topically to treat skin conditions such as eczema, burns and wounds. However, effects of A vera on AD were not fully elucidated. In this study, we investigated the oral administration of processed A vera gel (PAG) containing low molecular weight Aloe polysaccharides to treat ovalbumin (OVA)-induced AD in mice. Oral administration of PAG suppressed total and OVA-specific IgE production in sera and decreased the epidermal thickness of skin. Numbers of Ki-67-positive cells were reduced by PAG treatment. Expression levels of tight junction genes, including those that encode ZO-1, Claudin-1 and Claudin-8, were decreased in AD skin lesions, whereas oral administration of PAG partially restored the expression levels of tight junction genes. In addition, IL-4 and IL-17A mRNA transcript levels were reduced in skin lesions after PAG treatment. Taken together, our findings suggest that oral administration of PAG ameliorated AD, normalized tight junction gene expression and suppressed inflammatory cytokines in AD skin.

中文翻译：

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芦荟多糖口服治疗可通过恢复皮肤的紧密连接来改善卵白蛋白诱发的特应性皮炎。

特应性皮炎（AD）是一种慢性炎症性皮肤病。AD的标志是由表皮屏障功能缺陷导致的皮肤瘙痒干燥。芦荟被广泛用于促进整体健康，并局部给药以治疗皮肤状况，例如湿疹，烧伤和伤口。然而，尚未完全阐明维拉对AD的作用。在这项研究中，我们调查了含有低分子量芦荟多糖的经加工的A型维拉凝胶（PAG）的口服给药，以治疗卵白蛋白（OVA）诱导的小鼠AD。口服PAG可抑制血清中总的和OVA特异性IgE的产生，并减少皮肤的表皮厚度。通过PAG处理减少了Ki-67阳性细胞的数量。紧密连接基因的表达水平，包括编码ZO-1，Claudin-1和Claudin-8的基因，在AD皮肤病变中减少，而口服PAG部分恢复紧密连接基因的表达水平。此外，PAG治疗后皮肤病变中的IL-4和IL-17A mRNA转录水平降低。两者合计，我们的研究结果表明，口服PAG可以改善AD，使紧密连接基因表达正常化并抑制AD皮肤中的炎性细胞因子。