Nano-inspired technologies offer unique opportunities to treat numerous diseases by using therapeutic peptides. Therapeutic peptides have attractive pharmacological profiles and can be manufactured at relatively low costs. The major advantages of using a nanodelivery approach comprises significantly lower required dosages compared to systemic delivery, and thus reduced toxicity and immunogenicity. The combination of therapeutic peptides with delivery peptides and nanoparticles or small molecule drugs offers systemic treatment approaches, instead of aiming for single biological targets or pathways. This review article discusses exemplary state-of-the-art nanosized delivery systems for therapeutic peptides and antibodies, as well as their biochemical and biophysical foundations and emphasizes still remaining challenges. The competition between using different nanoplatforms, such as liposome-, hydrogel-, polymer-, silica nanosphere-, or nanosponge-based delivery systems is still "on" and no clear frontrunner has emerged to date.

中文翻译：

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纳米启发的肽递送技术。

纳米技术为使用治疗性肽治疗多种疾病提供了独特的机会。治疗性肽具有诱人的药理特性，可以较低的成本生产。与全身递送相比，使用纳米递送方法的主要优点包括大大降低了所需剂量，从而降低了毒性和免疫原性。治疗性肽与递送肽，纳米颗粒或小分子药物的结合提供了系统的治疗方法，而不是针对单一的生物学靶标或途径。这篇综述文章讨论了用于治疗性肽和抗体的示例性最新型纳米级递送系统，以及它们的生化和生物物理基础，并强调了仍然存在的挑战。