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Dengue transmission: mathematical model with discrete time delays and estimation of the reproduction number.
Journal of Biological Dynamics ( IF 1.8 ) Pub Date : 2019-01-08 , DOI: 10.1080/17513758.2018.1562572
Chunqing Wu 1 , Patricia J Y Wong 2
Affiliation  

In this paper, we establish a mathematical model with two delays to reflect the intrinsic and extrinsic incubation periods of virus in dengue transmission. The basic reproduction number R0 of the model is defined. It is proved that the disease-free equilibrium is stable when R0<1 and the positive equilibrium is stable when R0>1. Next, we derive an estimation formula for the reproduction number Rt when the human population is partially susceptible to dengue. As an application, the Rt values of dengue transmission in Singapore in the years 2013–2015 are estimated. Our estimation method can be applied to estimating Rt of other infectious diseases, especially when the human population is not completely susceptible to the disease.



中文翻译:

登革热传播:具有离散时间延迟并估计繁殖次数的数学模型。

在本文中,我们建立了具有两个延迟的数学模型,以反映登革热传播中病毒的内在和外在潜伏期。基本复制数[R0模型的定义。证明了在以下情况下无病平衡是稳定的[R0<1个 当以下情况时,正平衡是稳定的 [R0>1个。接下来,我们得出再现次数的估计公式[RŤ当人口部分易患登革热时。作为应用,[RŤ估计了2013-2015年新加坡的登革热传播值。我们的估计方法可以应用于估计[RŤ其他传染病,尤其是当人口完全易感时。

更新日期:2019-01-08
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