The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in synthetic polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability to carry both therapeutic cargo and targeting moieties. The combination of synthetic gene carrying constructs with advanced delivery techniques promises new therapeutic options for treating and curing genetic disorders. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.

中文翻译：

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聚合物介导的基因治疗：递送技术的最新进展和融合。

在复杂的生物环境中安全、精确地将遗传物质递送至目标位点的能力对于基因治疗的成功至关重要。已经开发了许多病毒和非病毒载体并对其安全性和有效性进行了评估。这项研究将重点介绍作为非病毒载体的合成聚合物的进展，其受益于其化学多功能性、生物相容性以及携带治疗货物和靶向部分的能力。合成基因携带结构与先进递送技术的结合为治疗和治愈遗传性疾病带来了新的治疗选择。本文的特点如下：治疗方法和药物发现>用于肿瘤疾病治疗方法和药物发现的纳米医学>新兴技术。