PURPOSE Digital PET/CT scanners represent a significant step forward in molecular imaging. We report here the clinical impact of digital PET in PSMA-PET/CT. METHODS In this retrospective study, 88 consecutive patients who underwent [68Ga]Ga-PSMA-11 PET/CT on a digital PET/CT (dPET/CT) scanner for recurrent prostate cancer (PC) were included in a first cohort. In a second step, 88 individuals who underwent an analogue [68Ga]Ga-PSMA-11 PET/CT (aPET/CT) were selected after they were matched to the first cohort for clinical parameters. Following consensus read by two nuclear medicine physicians, the number and type of PC lesions as well as benign, PSMA-positive lesions were recorded. The results were complemented by extensive [68Ga]Ga phantom measurements to determine imaging characteristics of both scanners. RESULTS dPET/CT revealed a greater number of PC lesions compared to aPET/CT (326 versus 142) as well as a proportional increase in benign causes of tracer-uptake (144 versus 65). A greater number of scans were noted as pathological for PC on dPET/CT (74/88) compared to aPET/CT (64/88, p < 0.05). The PSMA positivity rate for PC was significantly higher in dPET/CT for the lowest PSA values (PSA < 2.0 ng/ml, p < 0.05). CONCLUSION dPET/CT detected more PC lesions compared to aPET/CT. A significantly higher rate of pathological PET/CTs was noted in the group with the lowest PSA values. A higher number of benign PSMA-positive lesions were also noted in dPET/CT. The differences could be plausibly explained by the measured imaging characteristics of the scanners.

中文翻译：

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用于复发性前列腺癌的[68Ga] Ga-PSMA-11 PET / CT中的数字与模拟PET：配对比较。

用途数字PET / CT扫描仪代表了分子成像技术的重要进步。我们在这里报告了PSMA-PET / CT中数字PET的临床影响。方法在这项回顾性研究中，第一批队列研究包括88位连续患者，这些患者在数字PET / CT（dPET / CT）扫描仪上接受了[68Ga] Ga-PSMA-11 PET / CT。在第二步骤中，在与第一个队列的临床参数匹配后，选择了接受过模拟[68Ga] Ga-PSMA-11 PET / CT（aPET / CT）的88位个体。在两位核医学医师的共识下，记录了PC病变的数量和类型以及良性，PSMA阳性病变。通过广泛的[68Ga] Ga幻像测量来补充结果，以确定两个扫描仪的成像特性。结果与aPET / CT相比，dPET / CT显示更多的PC病变（326比142），并且示踪剂摄取的良性原因成比例增加（144比65）。相比aPET / CT（64/88，p <0.05），在dPET / CT上PC的病理学扫描次数更多（74/88）。在最低的PSA值（PSA <2.0 ng / ml，p <0.05）下，dPET / CT中PC的PSMA阳性率明显更高。结论dPET / CT比aPET / CT检测出更多的PC病变。PSA值最低的组中病理PET / CT的发生率显着更高。dPET / CT中还发现了更多的良性PSMA阳性病变。可以通过扫描仪的测量成像特性合理地解释这些差异。