The transcription factor Snai2, encoded by the SNAI2 gene, is an evolutionarily conserved C2H2 zinc finger protein that orchestrates biological processes critical to tissue development and tumorigenesis. Initially characterized as a prototypical epithelial-to-mesenchymal transition (EMT) transcription factor, Snai2 has been shown more recently to participate in a wider variety of biological processes, including tumor metastasis, stem and/or progenitor cell biology, cellular differentiation, vascular remodeling and DNA damage repair. The main role of Snai2 in controlling such processes involves facilitating the epigenetic regulation of transcriptional programs, and, as such, its dysregulation manifests in developmental defects, disruption of tissue homeostasis, and other disease conditions. Here, we discuss our current understanding of the molecular mechanisms regulating Snai2 expression, abundance and activity. In addition, we outline how these mechanisms contribute to disease phenotypes or how they may impact rational therapeutic targeting of Snai2 dysregulation in human disease.

中文翻译：

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Snai2在发育和疾病中的分子调控。

由SNAI2基因编码的转录因子Snai2是一种进化保守的C2H2锌指蛋白，可协调对组织发育和肿瘤发生至关重要的生物过程。Snai2最初被表征为原型上皮到间充质转化（EMT）转录因子，最近被证明参与更广泛的生物学过程，包括肿瘤转移，干细胞和/或祖细胞生物学，细胞分化，血管重塑和DNA损伤修复。Snai2在控制此类过程中的主要作用涉及促进转录程序的表观遗传调控，因此，其异常调节表现为发育缺陷，组织稳态的破坏和其他疾病状况。这里，我们讨论了我们目前对调节Snai2表达，丰度和活性的分子机制的理解。此外，我们概述了这些机制如何促成疾病表型或它们如何影响人类疾病中Snai2失调的合理治疗目标。