Although the nucleolus was first described in the early 19th century from both animal and plant cells, human nucleoli and particularly the five human nucleolus organizers have not been well characterized. In this issue of Genes & Development, van Sluis and colleagues (pp. 1688-1701) present a detailed molecular analysis of these organizers, which occur on the short arms of five human chromosomes. The near identity of these arms suggests extensive interchromosomal exchange during evolutionary history.

中文翻译：

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人类核仁组织者区域。

虽然核仁是在 19 世纪早期从动物和植物细胞中首次被描述的，但人类核仁，尤其是五种人类核仁组织者尚未得到很好的表征。在本期 Genes & Development 中，van Sluis 及其同事 (pp. 1688-1701) 对这些组织者进行了详细的分子分析，这些组织者发生在五个人类染色体的短臂上。这些臂的接近身份表明在进化历史中广泛的染色体间交换。