To evaluate the influence of low-concentration contrast agents and low-tube-voltage computed tomography on chest enhancement examinations, we conducted a multicenter prospective study. A total of 216 inpatients enrolled from 12 different hospitals were randomly divided into four groups: A: voltage, 120 kVp; iohexol, 350 mgI/mL; B: voltage, 100 kVp, iohexol, 350 mgI/mL; C: voltage, 120 kVp, iodixanol, 270 mgI/mL; and D: voltage, 100 kVp, iodixanol, 270 mgI/mL. Subjective image quality was assessed by two radiologists and compared by weighted kappa test. The objective image scores, scanning radiation doses, and pathological coincidence rates were analyzed. There were no significant differences in gender, age, height, weight, and body mass index between the four groups (p > 0.05). The consistency of the radiologists' ratings were good, with kappa value ranging from 0.736 (95% confidence interval: 0.54-0.933) to 0.809 (95% confidence interval: 0.65-0.968), and there was no difference in subjective image score between the four groups. The computed tomography value of group D had no difference with group A. The volume computed tomography dose index, dose length product, and effective dose of group D (6.93 ± 3.03, 241.55 ± 104.75, and 3.38 ± 1.47, respectively) were all significantly lower than those of group A (10.30 ± 4.37, 359.70 ± 152.65, and 5.04 ± 2.14, respectively). There was no significant difference in the imaging diagnosis accuracy rate between the four groups (p > 0.05). The results indicated that low-concentration contrast agents (270 mgI/mL) and low-tube-voltage (100 kVp) computed tomography can not only decrease radiation dose but also guarantee the image quality and meet the needs of imaging diagnosis in chest enhancement examinations, which make it possible for its generalization and application.

中文翻译：

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低浓度造影剂和低管电压计算机断层扫描在胸部增强检查中的应用：一项多中心前瞻性研究。

为了评估低浓度造影剂和低管电压计算机断层扫描对胸部增强检查的影响，我们进行了一项多中心前瞻性研究。来自12家不同医院的216名住院患者被随机分为四组：A：电压，120 kVp；碘海醇，350 mgI/mL；B：电压，100 kVp，碘海醇，350 mgI/mL；C：电压，120 kVp，碘克沙醇，270 mgI/mL；D：电压，100 kVp，碘克沙醇，270 mgI/mL。主观图像质量由两名放射科医生评估，并通过加权卡帕检验进行比较。分析客观图像评分、扫描辐射剂量和病理符合率。四组之间的性别、年龄、身高、体重和体重指数均无显着差异（p > 0.05）。放射科医生评分的一致性良好，kappa值范围为0.736（95%置信区间：0.54-0.933）至0.809（95%置信区间：0.65-0.968），并且各放射科医生之间的主观图像评分没有差异。四组。D组CT值与A组无差异。D组体积CT剂量指数、剂量长度乘积、有效剂量（分别为6.93±3.03、241.55±104.75、3.38±1.47）均显着升高。低于A组（分别为10.30±4.37、359.70±152.65和5.04±2.14）。四组影像诊断准确率差异无统计学意义（p>0.05）。结果表明，低浓度造影剂（270 mgI/mL）和低管电压（100 kVp）计算机断层扫描不仅可以降低辐射剂量，而且可以保证图像质量，满足胸部强化检查影像诊断的需要。 ，使其推广和应用成为可能。