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Expression of long non-coding RNA H19 predicts distant metastasis in minimally invasive follicular thyroid carcinoma.
Bioengineered ( IF 4.2 ) Pub Date : 2019-09-06 , DOI: 10.1080/21655979.2019.1658489
Yan Dai 1 , Yuanqing Miao 2 , Qingli Zhu 3 , Mei Gao 3 , Fengyun Hao 4
Affiliation  

Downregulation of lncRNA H19 (H19) expression is associated with an unfavorable prognosis in some cancers. However, little was known as to whether there was an association between H19 and minimally invasive follicular thyroid carcinoma (MI-FTC). In our study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to determine H19 expression in 186 patients with MI-FTC who underwent initial surgery. Of the 186 patients with MI-FTC, 21 patients show distant metastasis (M+)at the initial operation established the diagnosis of MI-FTC. Of the 165 patients who did not show distant metastasis at diagnosis during the follow-up period (≥10 years), 28 patients undergone M+ and 137 patients has no distant metastasis(M-)after the initial operation. Low H19 expression was associated with large tumor size, vascular invasion, and distant metastasis. Univariate analysis showed that gender (male), age (45 years or older), primary tumor size (4 cm or more), vascular invasion and H19 level (<1.12) were significant prognostic factors related to postoperative distant metastases. Multivariate analysis showed that age, primary tumor size (4 cm or more) and vascular invasion was a significant prognostic factor for survival. Patients with low H19 expression showed a poorer outcome in MI-FTC patients. Receiver-operating characteristic (ROC) curve analysis demonstrated H19 could distinguish M+ from M- patientswith a value of area under the curve (AUC). Our findings suggest that H19 is a potential prognostic factor for evaluating prognosis and the metastatic potential of MI-FTC at an initial operation stage.



中文翻译:

长时间非编码RNA H19的表达可预测微浸润性甲状腺滤泡癌的远处转移。

lncRNA H19(H19)表达的下调与某些癌症的不良预后有关。但是,关于H19与微浸润性甲状腺滤泡癌(MI-FTC)之间是否存在关联还知之甚少。在我们的研究中,我们使用定量实时聚合酶链反应(qRT-PCR)确定了186例行初次手术的MI-FTC患者的H19表达。在186例MI-FTC患者中,有21例在初诊时出现远处转移(M +),确诊为MI-FTC。随访期间(≥10年)未确诊为远处转移的165例患者中,初次手术后28例行M +检查,137例无远处转移(M-)。H19的低表达与肿瘤大,血管浸润和远处转移有关。单因素分析显示,性别(男性),年龄(45岁以上),原发肿瘤大小(4 cm或更大),血管浸润和H19水平(<1.12)是与术后远处转移相关的重要预后因素。多因素分析表明,年龄,原发肿瘤大小(4 cm或更大)和血管侵犯是生存的重要预后因素。H19表达低的患者在MI-FTC患者中显示出较差的结果。接收者操作特征(ROC)曲线分析表明,H19可以将M +与M-患者区分开,其曲线下面积(AUC)值。我们的发现表明,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。原发肿瘤大小(4 cm或更大),血管浸润和H19水平(<1.12)是与术后远处转移相关的重要预后因素。多因素分析表明,年龄,原发肿瘤大小(4 cm或更大)和血管侵犯是生存的重要预后因素。H19表达低的患者在MI-FTC患者中显示出较差的结果。接收者操作特征(ROC)曲线分析表明,H19可以将M +与M-患者区分开,其曲线下面积(AUC)值。我们的发现提示,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。原发肿瘤大小(4 cm或更大),血管浸润和H19水平(<1.12)是与术后远处转移相关的重要预后因素。多因素分析表明,年龄,原发肿瘤大小(4 cm或更大)和血管侵犯是生存的重要预后因素。H19表达低的患者在MI-FTC患者中显示出较差的结果。接收者操作特征(ROC)曲线分析表明,H19可以通过曲线下面积(AUC)的值将M +与M-患者区分开。我们的发现提示,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。多因素分析表明,年龄,原发肿瘤大小(4 cm或更大)和血管侵犯是生存的重要预后因素。H19表达低的患者在MI-FTC患者中显示出较差的结果。接收者操作特征(ROC)曲线分析表明,H19可以将M +与M-患者区分开,其曲线下面积(AUC)值。我们的发现提示,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。多因素分析表明,年龄,原发肿瘤大小(4 cm或更大)和血管侵犯是生存的重要预后因素。H19表达低的患者在MI-FTC患者中显示出较差的结果。接收者操作特征(ROC)曲线分析表明,H19可以将M +与M-患者区分开,其曲线下面积(AUC)值。我们的发现提示,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。接收者操作特征(ROC)曲线分析表明,H19可以将M +与M-患者区分开,其曲线下面积(AUC)值。我们的发现提示,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。接收者操作特征(ROC)曲线分析表明,H19可以将M +与M-患者区分开,其曲线下面积(AUC)值。我们的发现提示,H19是评估MI-FTC在初始手术阶段的预后和转移潜力的潜在预后因素。

更新日期:2019-09-06
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