Lower extremity ulcerations represent a major complication in diabetes mellitus and involve multiple physiological factors that lead to impairment of wound healing. Neuropeptides are neuromodulators implicated in various processes including diabetic wound healing. Diabetes causes autonomic and small sensory nerve fibers neuropathy as well as inflammatory dysregulation, which manifest with decreased neuropeptide expression and a disproportion in pro- and anti- inflammatory cytokine response. Therefore to fully understand the contribution of autonomic nerve dysfunction in diabetic wound healing it is crucial to explore the implication of neuropeptides. Here, we will discuss recent studies elucidating the role of specific neuropeptides in wound healing.

中文翻译：

---

自主神经功能障碍和糖尿病伤口愈合受损：神经肽的作用

下肢溃疡是糖尿病的主要并发症，涉及多种生理因素，导致伤口愈合受损。神经肽是涉及包括糖尿病伤口愈合在内的各种过程的神经调节剂。糖尿病会导致自主神经和小感觉神经纤维神经病变以及炎症失调，表现为神经肽表达降低和促炎和抗炎细胞因子反应不成比例。因此，要充分了解自主神经功能障碍在糖尿病伤口愈合中的作用，探索神经肽的意义至关重要。在这里，我们将讨论最近的研究，阐明特定神经肽在伤口愈合中的作用。