Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it was suggested that for the two DNA sequences to resonate, they do not necessarily have to be identical. Therefore, the existence of sequences differing in the primary sequence but having similar resonating sub-structures was proposed. It was hypothesized that such sequences, named HIDERs, would be enriched in the genomes of multicellular species. Specifically, it was hypothesized that delocalized electron clouds of purine-pyrimidine sequences could serve as the basis of HIDERs. The consequent computational genomic analysis confirmed the enrichment of purine-pyrimidine HIDERs in a few selected genomes of mammals, an insect, and a plant, compared to randomized sequence controls. Similarly, it was suggested that hypothetical delocalized proton clouds of the hydrogen bonds of multiple stacked bases could serve as sequence-dependent hydrogen-bond-based HIDERs. Similarly, the enrichment of such HIDERs was observed. It is suggested that these enrichments are the first evidence in support of sequence-specific resonance signaling in the genome.

尽管有关序列特异性DNA共振在生物学中的作用的理论已有40多年的历史了，但缺乏公开的证据。在此，作者认为，对于持续的共振信号传导，每个基因组的振荡DNA序列的数量应异常高，因此，各种大小的基因组重复序列可以用作共振器。此外，有人建议，要使两个DNA序列发生共振，它们不一定必须相同。因此，提出了存在主序列不同但具有相似的共振子结构的序列。据推测，这种名为HIDERs的序列将在多细胞物种的基因组中富集。特别，据推测，嘌呤-嘧啶序列的离域电子云可以作为HIDERs的基础。随后的计算基因组分析证实，与随机序列对照相比，嘌呤-嘧啶HIDERs在哺乳动物，昆虫和植物的几个选定基因组中富集。类似地，有人提出，多个堆叠碱基的氢键的假设离域质子云可以用作依赖序列的氢键基HIDER。类似地，观察到此类HIDER的富集。建议这些富集是支持基因组中序列特异性共振信号转导的第一个证据。随后的计算基因组分析证实，与随机序列对照相比，嘌呤-嘧啶HIDER在哺乳动物，昆虫和植物的几个选定基因组中富集。类似地，有人提出，多个堆叠碱基的氢键的假设离域质子云可以用作依赖序列的氢键基HIDER。类似地，观察到此类HIDER的富集。建议这些富集是支持基因组中序列特异性共振信号转导的第一个证据。随后的计算基因组分析证实，与随机序列对照相比，嘌呤-嘧啶HIDER在哺乳动物，昆虫和植物的几个选定基因组中富集。类似地，有人提出，多个堆叠碱基的氢键的假设离域质子云可以用作依赖序列的氢键基HIDER。类似地，观察到此类HIDER的富集。建议这些富集是支持基因组中序列特异性共振信号转导的第一个证据。观察到这类HIDER的富集。建议这些富集是支持基因组中序列特异性共振信号转导的第一个证据。观察到这类HIDER的富集。建议这些富集是支持基因组中序列特异性共振信号转导的第一个证据。