Fibroblasts have a central role in tissue fibrosis and fibrotic diseases. Fibroblast activation is regulated by several mechanisms including epigenetic modifications; histone modifications, DNA methylation and non-coding RNAs. Although research has significantly contributed to our basic understanding of fibrotic diseases over the last decade, cooperative activity of epigenetic mechanisms demonstrates the complexity of fibrogenesis. This review will summarise the latest epigenetic advances in fibroproliferative diseases. Current studies investigating biological implications of epigenetic modifiers, inhibitors of DNA methylation/histone modifying enzymes are promising. Given that ncRNA-based or CRISPR-based epigenetic-editing have shown therapeutic potential in the preclinical models; we consider epigenetic mechanisms represent a potential tool with clinical utility.

中文翻译：

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成纤维细胞生物学和纤维化疾病的表观遗传学研究进展。

成纤维细胞在组织纤维化和纤维化疾病中具有重要作用。成纤维细胞的激活受多种机制调控，包括表观遗传修饰；组蛋白修饰，DNA甲基化和非编码RNA。尽管在过去的十年中，研究为我们对纤维化疾病的基本理解做出了重要贡献，但表观遗传机制的协同活动证明了纤维化的复杂性。这篇综述将总结纤维增生性疾病的最新表观遗传学进展。目前研究表观遗传修饰剂，DNA甲基化/组蛋白修饰酶抑制剂的生物学意义的研究是有前途的。鉴于基于ncRNA或基于CRISPR的表观遗传学编辑已在临床前模型中显示了治疗潜力；