The electrical properties of neuronal cells rely on gradients of ions across their membranes and the extracellular fluid (ECF) in which they are bathed. Little is known regarding how the ECF volume and content is maintained. In this issue, Li et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907138) identify the kinase SIK3 in glia as a key signal transduction regulator in ion and volume homeostasis in Drosophila peripheral nerves.

中文翻译：

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胶质细胞 SIK3：果蝇周围神经离子和体积稳态的核心参与者

神经元细胞的电特性依赖于跨膜的离子梯度和它们所沐浴的细胞外液 (ECF)。关于如何维护 ECF 的数量和内容，人们知之甚少。在本期中，李等人。(2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907138) 确定神经胶质细胞中的激酶 SIK3 是果蝇周围神经离子和体积稳态的关键信号转导调节剂。